N-(5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide

Base Information

• Chemical Name: N-(5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide
• CAS No.: 925676-48-8
• Molecular Formula: C₁₈H₁₄FN₅O
• Molecular Weight: 335.34
• UNII: 3EBU6WKP85
• ChEMBL ID: CHEMBL1672627
• Pharos Ligand ID: 35R7Y6YXJL3Z
• Mol file: 925676-48-8.mol

Synonyms:925676-48-8;LAS101057;N-(5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide;LAS-101057;3EBU6WKP85;CHEMBL1672627;N-[5-(3-fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropanecarboxamide;N-[5-(3-FLUOROPYRIDIN-4-YL)-6-(PYRIDIN-3-YL)PYRAZIN-2-YL]CYCLOPROPANECARBOXAMIDE;N-(5-(3-Fluoro-4-pyridyl)-6-(3-pyridyl)pyrazin-2-yl)cyclopropanecarboxamide;Cyclopropanecarboxamide, N-(5-(3-fluoro-4-pyridinyl)-6-(3-pyridinyl)-2-pyrazinyl)-;CYCLOPROPANECARBOXAMIDE, N-[5-(3-FLUORO-4-PYRIDINYL)-6-(3-PYRIDINYL)-2-PYRAZINYL]-;UNII-3EBU6WKP85;C18H14FN5O;SCHEMBL3075657;BDBM50336977;MFCD18782728;AKOS037647409;CS-6718;LAS 101057;AS-73581;CID 16071896;HY-14390;W16537

Chemical Property of N-(5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide

Chemical Property:

• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 335.11823825
• Heavy Atom Count: 25
• Complexity: 474

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1C(=O)NC2=CN=C(C(=N2)C3=CN=CC=C3)C4=C(C=NC=C4)F

Technology Process of N-(5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide

There total 3 articles about N-(5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-(6-chloro-5-(3-fluoropyridine-4-yl)pyrazine-2-yl)cyclopropanecarboxamide (925678-05-3) + 3-pyridylboronic acid (1692-25-7) → LAS101057 (925676-48-8)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; at 90 ℃;

DOI:10.1021/ml100249e

Reference yield: 70.0%

→ LAS101057 (925676-48-8)

Guidance literature:

Reference yield:

6-chloro-5-(3-fluoropyridine-4-yl)pyrazine-2-amine (925678-04-2) → LAS101057 (925676-48-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 70 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane / 90 °C

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; 2: Suzuki coupling;

DOI:10.1021/ml100249e

upstream raw materials:

6-chloro-5-(3-fluoropyridine-4-yl)pyrazine-2-amine

N-(6-chloro-5-(3-fluoropyridine-4-yl)pyrazine-2-yl)cyclopropanecarboxamide

3-pyridylboronic acid