1-[(1S)-3α-Methyl-2α-(3-isopropylfuran-2-yl)cyclopentan-1α-yl]ethanone

Base Information

• Chemical Name: 1-[(1S)-3α-Methyl-2α-(3-isopropylfuran-2-yl)cyclopentan-1α-yl]ethanone
• CAS No.: 1143-46-0
• Molecular Formula: C₁₅H₂₂O₂
• Molecular Weight: 234.338
• Hs Code.: 2932190090
• Mol file: 1143-46-0.mol

Synonyms:Ethanone,1-[3-methyl-2-[3-(1-methylethyl)-2-furanyl]cyclopentyl]-, [1S-(1a,2a,3a)]-; Furopelargone B (7CI); Ketone,2-(3-isopropyl-2-furyl)-3-methylcyclopentyl methyl (8CI); Furopelargone B1

Chemical Property of 1-[(1S)-3α-Methyl-2α-(3-isopropylfuran-2-yl)cyclopentan-1α-yl]ethanone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 314.984°C at 760 mmHg
• Flash Point: 145.117°C
• PSA: 30.21000
• Density: 0.989g/cm³
• LogP: 4.12170

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[(1S)-3α-Methyl-2α-(3-isopropylfuran-2-yl)cyclopentan-1α-yl]ethanone

There total 6 articles about 1-[(1S)-3α-Methyl-2α-(3-isopropylfuran-2-yl)cyclopentan-1α-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

alpinenone (103425-23-6) → furopelargone B (1143-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 mg / lithium aluminium hydride / diethyl ether / 3 h / Ambient temperature

2: 15 mg / periodic acid / H₂O; dioxane / 0.17 h / Ambient temperature

With lithium aluminium tetrahydride; periodic acid; In 1,4-dioxane; diethyl ether; water;

Reference yield:

hanalpinol (94388-64-4) → furopelargone B (1143-46-0)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 17h; Ambient temperature;

DOI:10.1248/cpb.33.2023

Reference yield:

(1R,3aS,4R,8aR)-7-Isopropyl-1,4-dimethyl-1,2,3,3a,4,5,8,8a-octahydro-azulene-4,5,8-triol (103425-25-8,122125-34-2) → furopelargone B (1143-46-0)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 0.25h; Ambient temperature;

upstream raw materials:

hanalpinol

(1R,3aS,4R,8aR)-7-Isopropyl-1,4-dimethyl-1,2,3,3a,4,5,8,8a-octahydro-azulene-4,5,8-triol

(1R,3aS,4R,5R,8R,8aR)-7-Isopropyl-1,4-dimethyl-1,2,3,3a,4,5,8,8a-octahydro-azulene-4,5,8-triol

(1R,2R,3R,6S,7S)-10-Isopropyl-3,7-dimethyl-11,12-dioxa-tricyclo[5.3.2.0^2,6]dodec-9-en-8-ol

Downstream raw materials:

furopelargone A

5-((1R,2S,5R)-2-Acetyl-5-methyl-cyclopentyl)-4-isopropyl-3H-furan-2-one

Refernces

• 1、 Morita, Hiroshi,Simuzu, Katumasa,Takizawa, Harumi,Aiyama, Ritsuo,Itokawa, Hideji. "Studies on Chemical Conversion of Alpinenone to Furopelargone B". . p. 3156 - 3160. Retrieved 2007/10/02.