Phenol, 2-(1,1-dimethyl-2-propynyl)-

Base Information

• Chemical Name: Phenol, 2-(1,1-dimethyl-2-propynyl)-
• CAS No.: 92617-92-0
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.216
• Mol file: 92617-92-0.mol

Synonyms:

Chemical Property of Phenol, 2-(1,1-dimethyl-2-propynyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 2-(1,1-dimethyl-2-propynyl)-

There total 5 articles about Phenol, 2-(1,1-dimethyl-2-propynyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-bromo-4,4-dimethyl-4H-1-benzopyran → 3-(2-hydroxyphenyl)-3-methylbutyne (92617-92-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; 1) -78 deg C, 1 h 2) RT, 1 h;

DOI:10.1039/P29840001269

Reference yield:

4,4-dimethyl-2-oxo-chroman (29598-22-9) → 3-(2-hydroxyphenyl)-3-methylbutyne (92617-92-0)

Guidance literature:

Multi-step reaction with 5 steps

1: diisobutylaluminium hydride

2: 89 percent / toluene-p-sulphonic acid / benzene / 24 h / Heating; soxhlet extractor with 4A mol. sieves

3: Br₂, H₂O / tetrahydrofuran

4: toluene-p-sulphonic acid / benzene / 24 h / Heating; soxhlet extractor with 4A mol. sieves

5: 50 percent / n-butyllithium / tetrahydrofuran / 1) -78 deg C, 1 h 2) RT, 1 h

With n-butyllithium; water; bromine; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

DOI:10.1039/P29840001269

Reference yield:

4,4-dimethyl-4H-1-benzopyran (39689-29-7) → 3-(2-hydroxyphenyl)-3-methylbutyne (92617-92-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Br₂, H₂O / tetrahydrofuran

2: toluene-p-sulphonic acid / benzene / 24 h / Heating; soxhlet extractor with 4A mol. sieves

3: 50 percent / n-butyllithium / tetrahydrofuran / 1) -78 deg C, 1 h 2) RT, 1 h

With n-butyllithium; water; bromine; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;

DOI:10.1039/P29840001269

upstream raw materials:

4,4-dimethyl-2-oxo-chroman

4,4-dimethyl-4H-1-benzopyran

4,4-dimethyl-3,4-dihydro-2-hydroxy-2H-1-benzopyran

3-bromo-3,4-dihydro-2-hydroxy-4,4-dimethyl-2H-1-benzopyran