2-Pyrrolidinone, 3,4-dihydroxy-3-[(1R)-1-(phenylmethoxy)ethyl]-5-[(phenylmethoxy)methyl ]-, (3S,4S,5S)-

Base Information

• Chemical Name: 2-Pyrrolidinone, 3,4-dihydroxy-3-[(1R)-1-(phenylmethoxy)ethyl]-5-[(phenylmethoxy)methyl ]-, (3S,4S,5S)-
• CAS No.: 926318-88-9
• Molecular Formula: C21H25NO5
• Molecular Weight: 371.433
• Mol file: 926318-88-9.mol

Synonyms:

Chemical Property of 2-Pyrrolidinone, 3,4-dihydroxy-3-[(1R)-1-(phenylmethoxy)ethyl]-5-[(phenylmethoxy)methyl ]-, (3S,4S,5S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyrrolidinone, 3,4-dihydroxy-3-[(1R)-1-(phenylmethoxy)ethyl]-5-[(phenylmethoxy)methyl ]-, (3S,4S,5S)-

There total 15 articles about 2-Pyrrolidinone, 3,4-dihydroxy-3-[(1R)-1-(phenylmethoxy)ethyl]-5-[(phenylmethoxy)methyl ]-, (3S,4S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

C26H37NO10S (926318-87-8) → C21H25NO5 (926318-88-9) + C21H24O6

Guidance literature:

C₂₆H₃₇NO₁₀S; With sodium hydride; In dimethyl sulfoxide; at 20 ℃;

With hydrogenchloride; In methanol; Further stages.;

Reference yield:

C17H22O4 (926318-79-8) → C21H25NO5 (926318-88-9)

Guidance literature:

Multi-step reaction with 9 steps

1.1: n-BuLi / tetrahydrofuran / -18 °C

1.2: 97 percent / tetrahydrofuran / -18 °C

2.1: 96 percent / i-Pr₂NEt / CH₂Cl₂ / Heating

3.1: methyl iodide; water / acetonitrile / 50 °C

3.2: NaBH₄; CeCl₃*7H₂O / various solvent(s) / 0 °C

4.1: NaH / dimethylformamide / 0 °C

5.1: O₃; Ph₃P / CH₂Cl₂ / -78 °C

5.2: aq. CF₃CO₂H

6.1: N-iodosuccinimide; n-Bu₄NI / CH₂Cl₂

7.1: 79 percent / P₂O₅ / CHCl₃ / 0 °C

8.1: liquid NH₃ / propan-2-ol / 20 °C

8.2: 83 percent / Et₃N / 1,2-dimethoxy-ethane / -18 °C

9.1: NaH / dimethylsulfoxide / 20 °C

9.2: 52 percent / aq. HCl / methanol

With N-iodo-succinimide; n-butyllithium; ammonia; water; phosphorus pentoxide; tetra-(n-butyl)ammonium iodide; sodium hydride; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; methyl iodide; In tetrahydrofuran; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

C21H30O4S2 (926318-80-1) → C21H25NO5 (926318-88-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 96 percent / i-Pr₂NEt / CH₂Cl₂ / Heating

2.1: methyl iodide; water / acetonitrile / 50 °C

2.2: NaBH₄; CeCl₃*7H₂O / various solvent(s) / 0 °C

3.1: NaH / dimethylformamide / 0 °C

4.1: O₃; Ph₃P / CH₂Cl₂ / -78 °C

4.2: aq. CF₃CO₂H

5.1: N-iodosuccinimide; n-Bu₄NI / CH₂Cl₂

6.1: 79 percent / P₂O₅ / CHCl₃ / 0 °C

7.1: liquid NH₃ / propan-2-ol / 20 °C

7.2: 83 percent / Et₃N / 1,2-dimethoxy-ethane / -18 °C

8.1: NaH / dimethylsulfoxide / 20 °C

8.2: 52 percent / aq. HCl / methanol

With N-iodo-succinimide; ammonia; water; phosphorus pentoxide; tetra-(n-butyl)ammonium iodide; sodium hydride; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; methyl iodide; In dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

upstream raw materials:

C₂₆H₃₇NO₁₀S

C₁₇H₂₂O₄

C₂₁H₃₀O₄S₂

C₂₃H₃₄O₅S₂

Downstream raw materials:

C₃₃H₅₃NO₅Si₂