Cyclopropanecarboxamide, 1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chlorophenyl)[(3R)-3-[[(1,1-dimeth ylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]methyl]-2-thiazolyl]-

Base Information

• Chemical Name: Cyclopropanecarboxamide, 1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chlorophenyl)[(3R)-3-[[(1,1-dimeth ylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]methyl]-2-thiazolyl]-
• CAS No.: 926664-53-1
• Molecular Formula: C31H38ClN3O4SSi
• Molecular Weight: 612.265

Synonyms:

Chemical Property of Cyclopropanecarboxamide, 1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chlorophenyl)[(3R)-3-[[(1,1-dimeth ylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]methyl]-2-thiazolyl]-

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Technology Process of Cyclopropanecarboxamide, 1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chlorophenyl)[(3R)-3-[[(1,1-dimeth ylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]methyl]-2-thiazolyl]-

There total 1 articles about Cyclopropanecarboxamide, 1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chlorophenyl)[(3R)-3-[[(1,1-dimeth ylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]methyl]-2-thiazolyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

(S)-N-(5-(amino(2-chIorophenyl)methyl)thiazol-2-yl)-1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide (926664-52-0) + (3R)-3-<(tert-butyl)dimethylsilyloxy>-4-chlorobutanal (119136-98-0) → 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-((S)-(2-chlorophenyl)((R)-3-dimethyl-t-butylsilyIhydroxypyrroIidin-1-yl)methyl)thiazol-2-yl)cyclopropanecarboxamide (926664-53-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 25 ℃; for 1.08333h;

Reference yield: 62.0%

1-(benzo[d][1,3]dioxol-5-yl)-N-(5-((S)-(2-chlorophenyl)((R)-3-dimethyl-t-butylsilyIhydroxypyrroIidin-1-yl)methyl)thiazol-2-yl)cyclopropanecarboxamide (926664-53-1) → 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-((S)-(2-chlorophenyl)((R)-3-hydroxypyrrolidin-1-yl)methyl)thiazol-2-yl)cyclopropanecarboxamide

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 3h;

upstream raw materials:

(S)-N-(5-(amino(2-chIorophenyl)methyl)thiazol-2-yl)-1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide

(3R)-3-<(tert-butyl)dimethylsilyloxy>-4-chlorobutanal

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