Cyclopropanecarboxamide, 1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chloro-4-fluorophenyl)[(3R)-3-[[(1,1 -dimethylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]methyl]-2-thiazolyl]-

Base Information

Chemical Name:Cyclopropanecarboxamide, 1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chloro-4-fluorophenyl)[(3R)-3-[[(1,1 -dimethylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]methyl]-2-thiazolyl]-
CAS No.:926664-80-4
Molecular Formula:C31H37ClFN3O4SSi
Molecular Weight:630.255
Hs Code.:

Cyclopropanecarboxamide,
1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chloro-4-fluorophenyl)[(3R)-3-[[(1,1
-dimethylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]methyl]-2-thiazolyl]-

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Chemical Property of Cyclopropanecarboxamide, 1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chloro-4-fluorophenyl)[(3R)-3-[[(1,1 -dimethylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]methyl]-2-thiazolyl]-

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Technology Process of Cyclopropanecarboxamide, 1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chloro-4-fluorophenyl)[(3R)-3-[[(1,1 -dimethylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]methyl]-2-thiazolyl]-

There total 1 articles about Cyclopropanecarboxamide, 1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chloro-4-fluorophenyl)[(3R)-3-[[(1,1 -dimethylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]methyl]-2-thiazolyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 926664-74-6
(S)-N-(5-(amino(2-chloro-4-fluorophenyl)methyl)thiazol-2-yl)-1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide

: 119136-98-0
(3R)-3-<(tert-butyl)dimethylsilyloxy>-4-chlorobutanal

: 926664-80-4
1-(benzo[d] [1,3]dioxol-5-yl)-N-(5-((S)-((R)-3-(tert-butyldimethylsilyloxy)pyrrolidin-1-yl)(2-chloro-4-fluorophenyl)methyl)thiazol-2-yl)cyclopropanecarboxamide

Guidance literature:: (S)-N-(5-(amino(2-chloro-4-fluorophenyl)methyl)thiazol-2-yl)-1-(benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide; (3R)-3-<(tert-butyl)dimethylsilyloxy>-4-chlorobutanal; In methanol; at 20 ℃; for 0.0833333h;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 1h;