Peptide, atrial natriuretic

Base Information

• Chemical Name: Peptide, atrial natriuretic
• CAS No.: 88898-17-3
• Molecular Formula: C128H205 N45 O39 S2
• Molecular Weight: 3062.41
• Mol file: 88898-17-3.mol

Synonyms:alpha ANP;alpha ANP Dimer;alpha Atrial Natriuretic Peptide;alpha-ANP Dimer;alpha-Atrial Natriuretic Peptide;ANF;ANF (1-126);ANF (1-28);ANF (99-126);ANF Precursors;ANP;ANP (1-126);ANP (1-28);ANP Prohormone (99-126);ANP-(99-126);Atrial Natriuretic Factor;Atrial Natriuretic Factor (1-126);Atrial Natriuretic Factor (1-28);Atrial Natriuretic Factor (99-126);Atrial Natriuretic Factor Precursors;Atrial Natriuretic Factor Prohormone;Atrial Natriuretic Peptide;Atrial Natriuretic Peptide (1-126);Atrial Natriuretic Peptides;Atrial Pronatriodilatin;Atriopeptigen;Atriopeptin (1-28);Atriopeptin (99-126);Atriopeptin 126;Atriopeptin Prohormone (1-126);Atriopeptins;Auriculin;beta ANP;beta Atrial Natriuretic Peptide;beta-ANP;beta-Atrial Natriuretic Peptide;Cardiodilatin (99-126);Cardiodilatin Precursor;Cardionatrin I;Cardionatrin IV;gamma ANP (99-126);gamma Atrial Natriuretic Peptide;gamma-Atrial Natriuretic Peptide;Natriuretic Peptide, Atrial;Natriuretic Peptides, Atrial;Peptide, Atrial Natriuretic;Peptides, Atrial Natriuretic;Prepro ANP;Prepro Cardiodilatin Atrial Natriuretic Factor;Prepro CDD ANF;Prepro-ANP;Prepro-Cardiodilatin-Atrial Natriuretic Factor;Prepro-CDD-ANF;Pro ANF;Pro-ANF;ProANF;Proatrial Natriuretic Factor;Pronatriodilatin

Chemical Property of Peptide, atrial natriuretic

Chemical Property:

• Appearance/Colour: White lyophilised solid
• PSA: 1453.98000
• LogP: -1.81240
• Storage Temp.: −20°C
• Solubility.: 0.05 M acetic acid: 1 mg/mL, clear, colorless
• Water Solubility.: soluble in water
• XLogP3: -15.2
• Hydrogen Bond Donor Count: 55
• Hydrogen Bond Acceptor Count: 47
• Rotatable Bond Count: 108
• Exact Mass: 3063.5072791
• Heavy Atom Count: 214
• Complexity: 6910

Purity/Quality:

99%, ^*data from raw suppliers

Atrial Natriuretic Peptide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC(C)C(C(=O)NCC(=O)NC(C)C(=O)NC(CCC(=O)N)C(=O)NC(CO)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(=O)O)NC(=O)C(C(C)CC)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=CC=C3)NC(=O)C(CS)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)N
• Isomeric SMILES: CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)N
• Biological functions: As expected from the secretory stimulus, ANP acts to restore a blood volume increase to normal by decreasing the levels of sodium and water in mammals. In addition to the vascular effect, ANP augments cardiac performance. In eels, the effects of ANP on the brain and intestine are much more potent and efficacious, but the effect on the kidney is less efficacious than in mammals. ANP induces weak antidiuresis in eels, but brisk diuresis in trout. Comparative studies in eels suggest that the fundamental action of ANP is on sodium extrusion, but not water.
• Description: Atrial natriuretic peptide is the first cardiac hormone isolated from the atria with potent hypotensive and natriuretic/diuretic actions. It is a drug target for hypertension and cardiac/renal failure. The presence of a natriuretic factor in the rat heart was first reported in 1981; it was isolated in 1983 from the rat and human atria.
• Uses: Atrial Natriuretic Peptide rat has been used:In the absorption test to confirm the specificity of the anti-NP antibodies.To study the effects of atrial natriuretic peptide (ANP) on renal water and sodium regulation in rats.To study the integrated biological effects of ANP on myocardial infarction using mice models.
• Clinical Use: The plasma ANP concentration is routinely measured to diagnose cardiac failure. The N-terminal fragment of proANP (NT-proANP) is also measured for diagnosis because of its longer half-life in plasma. Synthetic human ANP is used for the treatment of acute heart failure. Many kits for the measurement of plasma ANP are sold by various companies. Recently, ANP has been gradually replaced by BNP for the diagnosis and treatment of cardiac failure because of its immediate secretion in the earlier phase. The plasma ANP concentration is routinely measured to diagnose cardiac failure. The N-terminal fragment of proANP (NT-proANP) is also measured for diagnosis because of its longer half-life in plasma. Synthetic human ANP (Carperitide1 or Hanp) is used for the treatment of acute heart failure. Many kits for the measurement of plasma ANP are sold by various companies. Recently, ANP has been gradually replaced by BNP for the diagnosis and treatment of cardiac failure because of its immediate secretion in the earlier phase. 28-peptide, vasodilator, that increases glomerular filtration and diuresis.

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