1-Piperidinecarboxylic acid, 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-, (1R)-1-[[4-amino-3-chloro-5-(trifluoromethyl)phenyl]methyl]-2-methoxy-2 -oxoethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-, (1R)-1-[[4-amino-3-chloro-5-(trifluoromethyl)phenyl]methyl]-2-methoxy-2 -oxoethyl ester
CAS No.:926904-32-7
Molecular Formula:C26H28ClF3N4O5
Molecular Weight:568.98
Hs Code.:

1-Piperidinecarboxylic acid,
4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-,
(1R)-1-[[4-amino-3-chloro-5-(trifluoromethyl)phenyl]methyl]-2-methoxy-2
-oxoethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperidinecarboxylic acid, 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-, (1R)-1-[[4-amino-3-chloro-5-(trifluoromethyl)phenyl]methyl]-2-methoxy-2 -oxoethyl ester

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Technology Process of 1-Piperidinecarboxylic acid, 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-, (1R)-1-[[4-amino-3-chloro-5-(trifluoromethyl)phenyl]methyl]-2-methoxy-2 -oxoethyl ester

There total 2 articles about 1-Piperidinecarboxylic acid, 4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-, (1R)-1-[[4-amino-3-chloro-5-(trifluoromethyl)phenyl]methyl]-2-methoxy-2 -oxoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 291509-61-0
3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

: 926904-31-6
(R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid methylester

: 926904-32-7
(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-methoxycarbonyl-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate

Guidance literature:: (R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-hydroxy-propionic acid methylester; 4-Nitrophenyl chloroformate; In tetrahydrofuran; pyridine; at 60 ℃; for 1.83333h;

3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one; In tetrahydrofuran; pyridine; at 20 - 100 ℃;

Reference yield:

: 291509-61-0
3-(4-piperidinyl)-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

: C₁₈H₁₄ClF₃N₂O₇

: 926904-32-7
(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-methoxycarbonyl-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 - 100 ℃;

Reference yield: 81.0%

: 926904-32-7
(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-methoxycarbonyl-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate

: 868383-87-3
4-(2-oxo-1,2,4,5-tetrahydro-benzo[d][1,3]diazepin-3-yl)-piperidin-1-carboxylic acid-(R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-carboxyethylester

Guidance literature:: (R)-2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-methoxycarbonyl-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 3.5h;

With hydrogenchloride; In water;