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Technology Process of N-hydroxy-7-(naphthalen-2-ylthio)heptanamide

N-hydroxy-7-(naphthalen-2-ylthio)heptanamide

Base Information
  • Chemical Name:N-hydroxy-7-(naphthalen-2-ylthio)heptanamide
  • CAS No.:926908-04-5
  • Molecular Formula:C17H21NO2S
  • Molecular Weight:303.41900
  • Hs Code.:
  • ChEMBL ID:CHEMBL2419279
  • DSSTox Substance ID:DTXSID50583131
  • Nikkaji Number:J2.453.181C
  • Wikidata:Q27077989
  • Mol file:926908-04-5.mol
N-hydroxy-7-(naphthalen-2-ylthio)heptanamide

Synonyms:HNHA;926908-04-5;N-hydroxy-7-(naphthalen-2-ylthio)heptanamide;histone deacetylase inhibitor VI;N-hydroxy-7-naphthalen-2-ylsulfanylheptanamide;N-hydroxy-7-(2-naphthalenylthio)-Heptanamide;7-(Naphthalen-2-ylsulfanyl)-heptanoic acid hydroxyamide;GTPL7911;CHEMBL2419279;N-HYDROXY-7-(NAPHTHALEN-2-YLSULFANYL)HEPTANAMIDE;SCHEMBL17141115;CHEBI:94741;DTXSID50583131;BMB90804;AKOS016371022;CCG-208687;Histone Deacetylase Inhibitor VI, HNHA;NCGC00263612-03;AS-66085;HY-118672;CS-0067736;N-hydroxy-7-(2-naphthalenylthio)heptanamide;D83880;N-Hydroxy-7-[(naphthalen-2-yl)sulfanyl]heptanamide;BRD-K76698671-001-01-1;Q27077989;Histone Deacetylase Inhibitor VI

Suppliers and Price of N-hydroxy-7-(naphthalen-2-ylthio)heptanamide
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Cayman Chemical
  • HNHA ≥98%
  • 5mg
  • $ 75.00
  • Cayman Chemical
  • HNHA ≥98%
  • 10mg
  • $ 140.00
  • Cayman Chemical
  • HNHA ≥98%
  • 25mg
  • $ 332.00
  • ApexBio Technology
  • HNHA
  • 5mg
  • $ 95.00
  • American Custom Chemicals Corporation
  • N-HYDROXY-7-(2-NAPHTHALENYLTHIO)-HEPTANAMIDE 95.00%
  • 5MG
  • $ 198.00
  • Ambeed
  • N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide 95%
  • 10mg
  • $ 102.00
  • Ambeed
  • N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide 95%
  • 5mg
  • $ 54.00
  • Ambeed
  • N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide 95%
  • 25mg
  • $ 242.00
  • Alfa Aesar
  • HNHA
  • 10mg
  • $ 167.00
  • AK Scientific
  • HNHA
  • 25mg
  • $ 513.00
Total 28 raw suppliers
Chemical Property of N-hydroxy-7-(naphthalen-2-ylthio)heptanamide
Chemical Property:
  • PSA：74.63000 
  • LogP:4.77870 
  • Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C 
  • Sensitive.:Light Sensitive 
  • Solubility.:≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide 
  • XLogP3:4.1
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:8
  • Exact Mass:303.12930009
  • Heavy Atom Count:21
  • Complexity:311
Purity/Quality:

97% *data from raw suppliers

HNHA ≥98% *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1=CC=C2C=C(C=CC2=C1)SCCCCCCC(=O)NO
  • Description HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity (IC50 = 100 nM). In human fibrosarcoma HT1080 cells, it induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression (IC50 ~ 7.5 μM). HNHA is at least as effective as SAHA in inhibiting tumor growth in a murine xenograph model in vivo. HNHA also blocks the growth of human umbilical vein endothelial cells (HUVECs) and prevents tube formation and migration of HUVECs in response to vascular endothelial growth factor (VEGF). It also blocks retinal neovascularization and choroidal angiogenesis in mice.
  • Uses A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity
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