Technology Process of 1alpha,3beta-Dihydroxy-24-nor-9,10-seco-5,7,10(19)-cholatrien-23-oic acid
There total 32 articles about 1alpha,3beta-Dihydroxy-24-nor-9,10-seco-5,7,10(19)-cholatrien-23-oic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol; water;
at 60 ℃;
for 1.5h;
DOI:10.1039/c4ra04322g
- Guidance literature:
-
Multi-step reaction with 10 steps
2: KOH / methanol; diethyl ether / 0.5 h / Ambient temperature
3: diethyl ether / 0.17 h / 0 °C / Irradiation
4: ethanol / 2.5 h / 80 °C
5: pyridine / 22 h / 4 °C
6: NaHCO3 / benzene / 18 h / 56 °C
7: 50 percent / SeO2, t-BuOOH / CH2Cl2 / 0.67 h / Ambient temperature
8: 0.25 h / 55 °C
9: KOH / methanol; diethyl ether / 1 h / 15 °C
10: KOH / methanol / 0.5 h / 60 °C
With
tert.-butylhydroperoxide; potassium hydroxide; selenium(IV) oxide; sodium hydrogencarbonate;
In
pyridine; methanol; diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1021/jo00315a047
- Guidance literature:
-
Multi-step reaction with 11 steps
3: KOH / methanol; diethyl ether / 0.5 h / Ambient temperature
4: diethyl ether / 0.17 h / 0 °C / Irradiation
5: ethanol / 2.5 h / 80 °C
6: pyridine / 22 h / 4 °C
7: NaHCO3 / benzene / 18 h / 56 °C
8: 50 percent / SeO2, t-BuOOH / CH2Cl2 / 0.67 h / Ambient temperature
9: 0.25 h / 55 °C
10: KOH / methanol; diethyl ether / 1 h / 15 °C
11: KOH / methanol / 0.5 h / 60 °C
With
tert.-butylhydroperoxide; potassium hydroxide; selenium(IV) oxide; sodium hydrogencarbonate;
In
pyridine; methanol; diethyl ether; ethanol; dichloromethane; benzene;
DOI:10.1021/jo00315a047
