26-Demethyl-12-deoxyoligomycin A

Base Information

Chemical Name:26-Demethyl-12-deoxyoligomycin A
CAS No.:92308-96-8
Molecular Formula:C₄₄H₇₂O₁₀
Molecular Weight:761.05
Hs Code.:

Synonyms:

Suppliers and Price of 26-Demethyl-12-deoxyoligomycin A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 26-Demethyl-12-deoxyoligomycin A

Chemical Property:

PSA：159.82000
LogP:6.52170

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 26-Demethyl-12-deoxyoligomycin A

There total 122 articles about 26-Demethyl-12-deoxyoligomycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 203064-05-5
rutamycin B tetra(tert-butyldimethyl)silyl ether

: 92308-96-8
rutamycin B

Guidance literature:: With hydrogen fluoride; In dichloromethane; acetonitrile; at 23 ℃; for 8h;
DOI:10.1021/ja00077a049

Reference yield:

: 131725-13-8
(2S,3S,4S,6R,8S,9S)-3,9-dimethyl-8-[(R)-2-hydroxy-1-propyl]-2-[(R)-3-(hydroxymethyl)-1-pentyl]-1,7-dioxaspiro[5.5]undecan-4-ol

: 92308-96-8
rutamycin B

Guidance literature:: Multi-step reaction with 16 steps

1.1: 13 mg / 2,6-lutidine / CH₂Cl₂ / 2.5 h / -78 °C

2.1: 90 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h

3.1: 44 percent / hydrofluoric acid*pyridine / tetrahydrofuran; pyridine / 11 h / 20 °C

4.1: 96 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / 2.33 h / -78 - 20 °C

5.1: 99 percent / lithium hydroxide monohydrate / methanol; tetrahydrofuran; H₂O / 20 h / 20 °C

6.1: 96 percent / DMAP / pyridine

7.1: 76 percent / diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C

8.1: 52 percent / titanium tetrachloride; i-Pr₂NEt / CH₂Cl₂ / 0.75 h / -78 - -50 °C

9.1: 86 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

10.1: 2,3-dichloro-5,6-dicyanobenzoquinone; water / CH₂Cl₂ / 0.5 h / 20 °C

10.2: 2,3-dichloro-5,6-dicyanobenzoquinone / CH₂Cl₂ / 0.5 h / 20 °C

11.1: 20.5 mg / Dess-Martin periodinate / CH₂Cl₂; pyridine; H₂O / 6 h / 20 °C

12.1: 54 percent / aq. hydrogen fluoride-pyridine / acetonitrile; CHCl₃ / 10 h / 20 °C

13.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 7 h / 20 °C

14.1: 88 percent / CrCl₂; lithium iodide / tetrahydrofuran / 5 h / 20 °C

15.1: 70 percent / PdCl₂(MeCN)2; Ph₃As; Ag₂O / tetrahydrofuran; H₂O / 2 h / 20 °C

16.1: 70 percent / HF; pyridine / acetonitrile; CH₂Cl₂ / 96 h

With pyridine; 2,6-dimethylpyridine; chromium dichloride; dmap; dichloro bis(acetonitrile) palladium(II); lithium hydroxide; n-butyllithium; oxalyl dichloride; triphenyl-arsane; hydrogen fluoride; water; titanium tetrachloride; Dess-Martin periodane; pyridine hydrogenfluoride; dimethyl sulfoxide; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; lithium iodide; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; chloroform; water; acetonitrile; 4.1: Swern oxidation / 7.1: Wadsworth-Emmons condensation;
DOI:10.1021/jo0104429

Reference yield:

: 203063-84-7
(2S,3S,4S,6R,8S,9S)-3,9-dimethyl-8-{(R)-2-[(tert-butyldimethylsilyl)-oxy]-1-propyl}-2-[(R)-3-ethyl-5-(E)-iodo-4-pentenyl]-1,7-dioxaspiro[5.5]undecan-4-ol

: 92308-96-8
rutamycin B

Guidance literature:: Multi-step reaction with 11 steps

1.1: 96 percent / DMAP / pyridine

2.1: 76 percent / diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C

3.1: 52 percent / titanium tetrachloride; i-Pr₂NEt / CH₂Cl₂ / 0.75 h / -78 - -50 °C

4.1: 86 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

5.1: 2,3-dichloro-5,6-dicyanobenzoquinone; water / CH₂Cl₂ / 0.5 h / 20 °C

5.2: 2,3-dichloro-5,6-dicyanobenzoquinone / CH₂Cl₂ / 0.5 h / 20 °C

6.1: 20.5 mg / Dess-Martin periodinate / CH₂Cl₂; pyridine; H₂O / 6 h / 20 °C

7.1: 54 percent / aq. hydrogen fluoride-pyridine / acetonitrile; CHCl₃ / 10 h / 20 °C

8.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 7 h / 20 °C

9.1: 88 percent / CrCl₂; lithium iodide / tetrahydrofuran / 5 h / 20 °C

10.1: 70 percent / PdCl₂(MeCN)2; Ph₃As; Ag₂O / tetrahydrofuran; H₂O / 2 h / 20 °C

11.1: 70 percent / HF; pyridine / acetonitrile; CH₂Cl₂ / 96 h

With pyridine; 2,6-dimethylpyridine; chromium dichloride; dmap; dichloro bis(acetonitrile) palladium(II); n-butyllithium; triphenyl-arsane; hydrogen fluoride; water; titanium tetrachloride; Dess-Martin periodane; pyridine hydrogenfluoride; diisopropylamine; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; lithium iodide; In tetrahydrofuran; pyridine; hexane; dichloromethane; chloroform; water; acetonitrile; 2.1: Wadsworth-Emmons condensation;
DOI:10.1021/jo0104429