9-(3-Amino-2-hydroxypropyl)-6-dimethylaminopurine dihydrochloride

Base Information

Chemical Name:9-(3-Amino-2-hydroxypropyl)-6-dimethylaminopurine dihydrochloride
CAS No.:86626-13-3
Molecular Formula:C₁₀H₁₆N₆O*2ClH
Molecular Weight:309.199
Hs Code.:
DSSTox Substance ID:DTXSID501006955

Synonyms:9-(3-Amino-2-hydroxypropyl)-6-dimethylaminopurine dihydrochloride;86626-13-3;alpha-(Aminomethyl)-6-(dimethylamino)-9H-purine-9-ethanol dihydrochloride;9H-Purine-9-ethanol, alpha-(aminomethyl)-6-(dimethylamino)-, dihydrochloride;C10H16N6O.2ClH;DTXSID501006955;C10-H16-N6-O.2Cl-H;LS-127081;1-Amino-3-[6-(dimethylamino)-9H-purin-9-yl]propan-2-ol--hydrogen chloride (1/2)

Suppliers and Price of 9-(3-Amino-2-hydroxypropyl)-6-dimethylaminopurine dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-(3-Amino-2-hydroxypropyl)-6-dimethylaminopurine dihydrochloride

Chemical Property:

Vapor Pressure:1.28E-10mmHg at 25°C
Boiling Point:495.1°Cat760mmHg
Flash Point:253.2°C
Density:g/cm³
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:308.0919146
Heavy Atom Count:19
Complexity:251

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C1=NC=NC2=C1N=CN2CC(CN)O.Cl.Cl

Technology Process of 9-(3-Amino-2-hydroxypropyl)-6-dimethylaminopurine dihydrochloride

There total 9 articles about 9-(3-Amino-2-hydroxypropyl)-6-dimethylaminopurine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 86626-12-2
9-(3-azido-2-hydroxypropyl)-6-dimethylaminopurine

: 86626-13-3
9-(3-amino-2-hydroxypropyl)-6-dimethylaminopurine dihydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; platinum(IV) oxide; In methanol; for 1.5h; under 2327.2 Torr;

Reference yield:

: 86626-07-5
6-dimethylamino-9-(3-benzyloxy-2-hydroxypropyl)purine

: 86626-13-3
9-(3-amino-2-hydroxypropyl)-6-dimethylaminopurine dihydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / triethylamine / acetonitrile / 1 h / Ambient temperature

2: 64 percent / H₂, conc. HCl / 5percent Pd/C, 20percent PdCl₂ / methanol / 3.5 h / 2327.2 Torr

3: 82 percent / pyridine / 16 h / Ambient temperature

4: 82 percent / NaN₃ / dimethylsulfoxide / 16 h / heating on a steam bath

5: 87 percent / 0.04 M sodium methoxide / methanol / 4.5 h / Ambient temperature

6: 67 percent / H₂, conc. HCl / PtO₂ / methanol / 1.5 h / 2327.2 Torr

With pyridine; hydrogenchloride; sodium azide; hydrogen; sodium methylate; triethylamine; platinum(IV) oxide; palladium on activated charcoal; palladium dichloride; In methanol; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 86626-09-7
9-(2-benzoyloxypropyl-3-hydroxy)-6-dimethylaminopurine

: 86626-13-3
9-(3-amino-2-hydroxypropyl)-6-dimethylaminopurine dihydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / pyridine / 16 h / Ambient temperature

2: 82 percent / NaN₃ / dimethylsulfoxide / 16 h / heating on a steam bath

3: 87 percent / 0.04 M sodium methoxide / methanol / 4.5 h / Ambient temperature

4: 67 percent / H₂, conc. HCl / PtO₂ / methanol / 1.5 h / 2327.2 Torr

With pyridine; hydrogenchloride; sodium azide; hydrogen; sodium methylate; platinum(IV) oxide; In methanol; dimethyl sulfoxide;