Phosphoric acid, [6-(2,4-difluorophenoxy)-3-(2,5-difluorophenyl)-4-[[2-(methylsulfonyl)ethyl ]amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl bis(1,1-dimethylethyl) ester

Base Information

• Chemical Name: Phosphoric acid, [6-(2,4-difluorophenoxy)-3-(2,5-difluorophenyl)-4-[[2-(methylsulfonyl)ethyl ]amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl bis(1,1-dimethylethyl) ester
• CAS No.: 928033-48-1
• Molecular Formula: C29H34F4N5O7PS
• Molecular Weight: 703.652

Synonyms:

Chemical Property of Phosphoric acid, [6-(2,4-difluorophenoxy)-3-(2,5-difluorophenyl)-4-[[2-(methylsulfonyl)ethyl ]amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl bis(1,1-dimethylethyl) ester

Chemical Property:

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Useful:

Technology Process of Phosphoric acid, [6-(2,4-difluorophenoxy)-3-(2,5-difluorophenyl)-4-[[2-(methylsulfonyl)ethyl ]amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl bis(1,1-dimethylethyl) ester

There total 1 articles about Phosphoric acid, [6-(2,4-difluorophenoxy)-3-(2,5-difluorophenyl)-4-[[2-(methylsulfonyl)ethyl ]amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl bis(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[6-(2,4-difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-(2-methanesulfonyl-ethyl)-amine (928033-50-5) + di-tert-butyl chloromethyl phosphate (229625-50-7) → phosphoric acid di-tert-butyl ester 6-(2,4-difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-4-(2-methanesulfonyl-ethylamino)-pyrazolo[3,4-d]pyrimidin-1-ylmethyl ester (928033-48-1)

Guidance literature:

With caesium carbonate; In acetonitrile; at 80 ℃; for 2h;

Reference yield:

phosphoric acid di-tert-butyl ester 6-(2,4-difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-4-(2-methanesulfonyl-ethylamino)-pyrazolo[3,4-d]pyrimidin-1-ylmethyl ester (928033-48-1) → phosphoric acid mono-[6-(2,4-difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-4-(2-methanesulfonyl-ethylamino)-pyrazolo[3,4-d]pyrimidin-1-ylmethyl]ester (928033-38-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;

upstream raw materials:

[6-(2,4-difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-(2-methanesulfonyl-ethyl)-amine

di-tert-butyl chloromethyl phosphate

Downstream raw materials:

phosphoric acid mono-[6-(2,4-difluoro-phenoxy)-3-(2,5-difluoro-phenyl)-4-(2-methanesulfonyl-ethylamino)-pyrazolo[3,4-d]pyrimidin-1-ylmethyl]ester

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