Technology Process of 1,2-Pyrrolidinedicarboxylic acid,
3-hydroxy-4-[2-methoxy-2-oxo-1-[(phenylmethoxy)amino]ethyl]-,
2-methyl 1-(phenylmethyl) ester, (2S,3S,4S)-
There total 8 articles about 1,2-Pyrrolidinedicarboxylic acid,
3-hydroxy-4-[2-methoxy-2-oxo-1-[(phenylmethoxy)amino]ethyl]-,
2-methyl 1-(phenylmethyl) ester, (2S,3S,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2: sulfuric acid / 10 h / Reflux
3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 17 h / 20 °C / Inert atmosphere
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 6.5 h / Inert atmosphere; Reflux
5: 3-chloro-benzenecarboperoxoic acid; 6,6'-di-tert-butyl-4,4'-thiodi-o-cresol / 1,2-dichloro-ethane / 10 h / Inert atmosphere; Reflux
6: magnesium iodide / toluene; diethyl ether / 2 h / 0 °C / Inert atmosphere
7: triethyl borane / toluene; dichloromethane / 20.5 h / Inert atmosphere; Reflux
With
triethyl borane; sulfuric acid; 6,6'-di-tert-butyl-4,4'-thiodi-o-cresol; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; magnesium iodide; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; toluene;
3: |Mitsunobu Displacement;
DOI:10.1016/j.tet.2013.06.006
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 17 h / 20 °C / Inert atmosphere
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 6.5 h / Inert atmosphere; Reflux
3: 3-chloro-benzenecarboperoxoic acid; 6,6'-di-tert-butyl-4,4'-thiodi-o-cresol / 1,2-dichloro-ethane / 10 h / Inert atmosphere; Reflux
4: magnesium iodide / toluene; diethyl ether / 2 h / 0 °C / Inert atmosphere
5: triethyl borane / toluene; dichloromethane / 20.5 h / Inert atmosphere; Reflux
With
triethyl borane; 6,6'-di-tert-butyl-4,4'-thiodi-o-cresol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; magnesium iodide; diethylazodicarboxylate;
In
tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; toluene;
1: |Mitsunobu Displacement;
DOI:10.1016/j.tet.2013.06.006
