6-Amino-2,3-dihydro-benzo[1,4]oxazine-4-carboxylic acid tert-butyl ester

Base Information

Chemical Name:6-Amino-2,3-dihydro-benzo[1,4]oxazine-4-carboxylic acid tert-butyl ester
CAS No.:928118-00-7
Molecular Formula:C13H18N2O3
Molecular Weight:250.29400
Hs Code.:2934999090
DSSTox Substance ID:DTXSID00696240
Wikidata:Q82625759
Mol file:928118-00-7.mol

Synonyms:928118-00-7;6-AMINO-2,3-DIHYDRO-BENZO[1,4]OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl 6-amino-2,3-dihydro-1,4-benzoxazine-4-carboxylate;tert-Butyl 6-amino-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate;tert-butyl 6-amino-3,4-dihydro-2H-1,4-benzoxazine-4-carboxylate;SCHEMBL2363147;DTXSID00696240;DFISCAMARWIZIY-UHFFFAOYSA-N;MFCD09953419;tert-butyl 6-amino-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxylate;SB39990;BS-29819;CS-0210772;FT-0741049;F19998;t-Butyl 6-amino-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate;tert-Butyl 6-amino-2,3-dihydro-4H-1,4-benzoxazine-4-carboxylate;6-amino-2,3-dihydrobenzo[1,4]oxazine-4-carboxylic acid tert-butyl ester

Suppliers and Price of 6-Amino-2,3-dihydro-benzo[1,4]oxazine-4-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
6-Amino-2,3-dihydro-benzo[1,4]oxazine-4-carboxylicacidtert-butylester 98%
5g
$ 360.00

J&W Pharmlab
6-Amino-2,3-dihydro-benzo[1,4]oxazine-4-carboxylicacidtert-butylester 98%
1g
$ 120.00

American Custom Chemicals Corporation
6-AMINO-2,3-DIHYDRO-BENZO(1,4)OXAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 97.00%
5G
$ 4966.50

AK Scientific
6-Amino-2,3-dihydro-benzo[1,4]oxazine-4-carboxylicacidtert-butylester
5g
$ 531.00

Total 6 raw suppliers

Chemical Property of 6-Amino-2,3-dihydro-benzo[1,4]oxazine-4-carboxylic acid tert-butyl ester

Chemical Property:

PSA：64.79000
LogP:3.04890
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:250.13174244
Heavy Atom Count:18
Complexity:314

Purity/Quality:

97% ^*data from raw suppliers

6-Amino-2,3-dihydro-benzo[1,4]oxazine-4-carboxylicacidtert-butylester 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCOC2=C1C=C(C=C2)N

Technology Process of 6-Amino-2,3-dihydro-benzo[1,4]oxazine-4-carboxylic acid tert-butyl ester

There total 4 articles about 6-Amino-2,3-dihydro-benzo[1,4]oxazine-4-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 928118-23-4
tert-butyl 6-nitro-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate

: 928118-00-7
tert-butyl 6-amino-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate

Guidance literature:: With hydrogen; Raney Ni; In ethanol; under 2068.65 Torr;

Reference yield:

: 99-57-0
2-hydroxy-5-nitroaniline

: 928118-00-7
tert-butyl 6-amino-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water / 0.5 h / 0 °C

1.2: Reflux

2.1: borane-THF / tetrahydrofuran / 2 h / Reflux

2.2: 1 h / Reflux

3.1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 0 °C

3.2: 2 h / 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h / 20 °C

With borane-THF; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2013.04.005

Reference yield:

: 81721-87-1
6-nitro-4H-benzo[1,4]oxazin-3-one

: 928118-00-7
tert-butyl 6-amino-2H-benzo[b][1,4]oxazine-4(3H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 2 h / Reflux

1.2: 1 h / Reflux

2.1: sodium hydrogencarbonate / dichloromethane / 0.5 h / 0 °C

2.2: 2 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 2 h / 20 °C

With borane-THF; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2013.04.005