Dihydrocanadensolide

Base Information

Chemical Name:Dihydrocanadensolide
CAS No.:20421-32-3
Molecular Formula:C11H16O4
Molecular Weight:212.24
Hs Code.:

Synonyms:(3S,3aS,6R,6aR)-6-butyl-3-methyltetrahydrofuro[3,4-b]furan-2,4-dione;(3S,3aS,6R,6aR)-6-Butyl-3-methyl-tetrahydro-furo[3,4-b]furan-2,4-dione;Dihydrocanadensolid;(3S,3aS,6R,6aR)-6-butyl-3-methyltetrahydrofuro-[3,4-b]furan-2,4-dione;6-butyl-3-methyl-(3S,3aS,6R,6aR)-perhydrofuro[3,4-b]furan-2,4-dione;

Suppliers and Price of Dihydrocanadensolide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Dihydrocanadensolide

Chemical Property:

PSA：52.60000
LogP:1.27970

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Dihydrocanadensolide

There total 15 articles about Dihydrocanadensolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 370887-86-8
6-butyl-4-hydroxy-3-methyl-(3S,3aS,6R,6aR)-perhydrofuro[3,4-b]furan-2-one

: 20421-32-3
(3S,3aS,6R,6aR)-6-butyl-3-methyltetrahydrofuro-[3,4-b]furan-2,4-dione

Guidance literature:: With dipyridinium dichromate; In dichloromethane; for 2h; Heating;
DOI:10.1016/S0040-4039(01)01168-6

Reference yield:

: 89755-93-1
5-butyl-2,2-dimethyl-(3aR,5R,6S,6aR)-perhydrofuro[2,3-d][1,3]dioxol-6-ol

: 20421-32-3
(3S,3aS,6R,6aR)-6-butyl-3-methyltetrahydrofuro-[3,4-b]furan-2,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / NaH / tetrahydrofuran / 4.5 h / 0 - 20 °C

2: 60 percent / hydrochloric acid / H₂O / 0.75 h / Heating

3: 81 percent / NaH / tetrahydrofuran / 5 h / 0 - 20 °C

4: tri-n-butyltin hydride; 2,2'-azobisisobutyronitrile / benzene / 12.5 h / Heating

5: 51 percent / NaIO₄; RuCl₃*H₂O / CCl₄; acetonitrile; H₂O / 18 h / 20 °C

6: 71 percent / acetic acid; hydrochloric acid / H₂O / 0.5 h / 60 °C

7: 68 percent / pyridinium dichromate / CH₂Cl₂ / 2 h / Heating

With hydrogenchloride; ruthenium trichloride; sodium periodate; dipyridinium dichromate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; acetic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile; benzene;
DOI:10.1016/S0040-4020(03)01068-8

Reference yield:

: 20031-21-4
1,2-O-isopropylidene-α-D-xylose

: 20421-32-3
(3S,3aS,6R,6aR)-6-butyl-3-methyltetrahydrofuro-[3,4-b]furan-2,4-dione

Guidance literature:: Multi-step reaction with 9 steps

1: 82 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

2: 75 percent / tetrahydrofuran / 10 h / Heating

3: 83 percent / NaH / tetrahydrofuran / 4.5 h / 0 - 20 °C

4: 60 percent / hydrochloric acid / H₂O / 0.75 h / Heating

5: 81 percent / NaH / tetrahydrofuran / 5 h / 0 - 20 °C

6: tri-n-butyltin hydride; 2,2'-azobisisobutyronitrile / benzene / 12.5 h / Heating

7: 51 percent / NaIO₄; RuCl₃*H₂O / CCl₄; acetonitrile; H₂O / 18 h / 20 °C

8: 71 percent / acetic acid; hydrochloric acid / H₂O / 0.5 h / 60 °C

9: 68 percent / pyridinium dichromate / CH₂Cl₂ / 2 h / Heating

With pyridine; hydrogenchloride; ruthenium trichloride; sodium periodate; dipyridinium dichromate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; acetic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile; benzene;
DOI:10.1016/S0040-4020(03)01068-8