AS 1892802

Base Information

• Chemical Name: AS 1892802
• CAS No.: 928320-12-1
• Molecular Formula: C₂₀H₁₉N₃O₂
• Molecular Weight: 333.39
• Mol file: 928320-12-1.mol

Synonyms:

Chemical Property of AS 1892802

Chemical Property:

• Boiling Point: 531.2±50.0 °C (760 mmHg)
• PKA: 12.42±0.46(Predicted)
• PSA: 74.25000
• Density: 1.256±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 4.06760
• Solubility.: Soluble in DMSO

Purity/Quality:

97% ^*data from raw suppliers

AS 1892802 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: AS 1892802 is a potent, ATP-competitive ROCK inhibitor. It also inhibits PKAC-α and PRKX and exhibits analgesic effects in rat models of inflammatory (AIA) and noninflammatory (MIA) arthritic pain.

Technology Process of AS 1892802

There total 15 articles about AS 1892802 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

phenyl 4-(pyridin-4-yl)phenylcarbamate (1357473-72-3) + D-2-phenylglycinol (56613-80-0) → (R)-1-(2-hydroxy-1-phenylethyl)-3-(4-(pyridin-4-yl)phenyl)urea (928320-12-1)

Guidance literature:

In dimethyl sulfoxide; at 90 ℃; for 14h;

DOI:10.1021/jm201289r

Reference yield: 47.0%

phenyl 4-(pyridin-4-yl)phenylcarbamate (1357473-72-3) + (2S)-2-phenylglycinol (20989-17-7) → AS1892802 (928320-12-1)

Guidance literature:

In dimethyl sulfoxide; at 90 ℃; for 14h;

DOI:10.1021/jm201289r

Reference yield: 47.0%

→ (R)-1-(2-hydroxy-1-phenylethyl)-3-(4-(pyridin-4-yl)phenyl)urea (928320-12-1)

Guidance literature:

In dimethyl sulfoxide; at 90 ℃; for 14h;

upstream raw materials:

4-nitrophenyl [4-(4-pyridinyl)phenyl]carbamate

(2S)-2-phenylglycinol

phenyl 4-(pyridin-4-yl)phenylcarbamate

4-(pyridin-4-yl)aniline