Dslet

Base Information

• Chemical Name: Dslet
• CAS No.: 75644-90-5
• Molecular Formula: C33H46 N6 O10
• Molecular Weight: 686.762
• DSSTox Substance ID: DTXSID00997082
• Nikkaji Number: J366.392B
• Wikidata: Q27077121
• ChEMBL ID: CHEMBL124283
• Mol file: 75644-90-5.mol

Synonyms:2-Ser-Thr-Leu-enkephalin;D-Ser(2), Leu(5), Thr(6)-enkephalin;D-Ser2,Thr6-Leucine-enkephalin;DSLET;DSTLE;enkephalin, D-Ser(2), Leu(5), Thr(6)-;enkephalin, Ser(2), Leu(5), Thr(6)-;enkephalin-Leu, Ser(2)-Thr-;enkephalin-Leu, seryl(2)-threonine-;Leu-enkephalin, Ser(2)-Thr-;leucine-enkephalin, Ser(2)-Thr-;Ser(2), Leu(5), Thr(6)-enkephalin;Ser(2)-Leu(5)-enkephalin-Thr(6);Tyr-Ser-Gly-Phe-Leu-Thr;tyrosyl-seryl-glycyl-phenylalanyl-leucyl-threonine

Chemical Property of Dslet

Chemical Property:

• Appearance/Colour: White lyophilised solid
• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1163 °C at 760 mmHg
• Flash Point: 657.2 °C
• PSA: 269.51000
• Density: 1.319 g/cm³
• LogP: 0.71870
• Storage Temp.: -15°C
• XLogP3: -3
• Hydrogen Bond Donor Count: 10
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 19
• Exact Mass: 686.32754169
• Heavy Atom Count: 49
• Complexity: 1110

Purity/Quality:

99%, ^*data from raw suppliers

DSLET ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(C(C)O)C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)C(CO)NC(=O)C(CC2=CC=C(C=C2)O)N
• Isomeric SMILES: C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H](CO)NC(=O)[C@H](CC2=CC=C(C=C2)O)N)O

Technology Process of Dslet

There total 7 articles about Dslet which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(tert-butyloxycarbonyl)-L-tyrosyl-O-tert-butyl-D-serylglycyl-L-phenylalanyl-L-leucyl-O-tert-butyl-L-threonine (78537-18-5) → [D-Ser(2)]-leucine enkephalin-Thr (75644-90-5)

Guidance literature:

With hydrogenchloride; trifluoroacetic acid; a) 0 deg C, 30 min, b) RT, 30 min;

DOI:10.1021/jm00142a002

Reference yield:

Boc-Tyr-OH (3978-80-1) → [D-Ser(2)]-leucine enkephalin-Thr (75644-90-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 89 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl₃ / a) 0 deg C, 1 h, b) RT, overnight

2: 94 percent / 1 N NaOH / methanol / a) 0 deg C, 30 min, b) RT, 2 h

3: 60 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl₃ / a) 0 deg C, 1 h, b) RT, overnight

4: 80 percent / 1 N NaOH / methanol / a) 0 deg C, 1 h, b) RT, 20 h

5: 90 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl₃ / a) 0 deg C, 1 h, b) RT, 20 h

6: 85 percent / 1 N NaOH / methanol / a) 0 deg C, 30 min, b) RT, 20 h

7: 90 percent / TFA, HCl / a) 0 deg C, 30 min, b) RT, 30 min

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; chloroform;

DOI:10.1021/jm00142a002

Reference yield:

N-(tert-butyloxycarbonyl)-L-tyrosyl-O-tert-butyl-D-serine methyl ester (78537-13-0) → [D-Ser(2)]-leucine enkephalin-Thr (75644-90-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 94 percent / 1 N NaOH / methanol / a) 0 deg C, 30 min, b) RT, 2 h

2: 60 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl₃ / a) 0 deg C, 1 h, b) RT, overnight

3: 80 percent / 1 N NaOH / methanol / a) 0 deg C, 1 h, b) RT, 20 h

4: 90 percent / triethylamine, 1-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CHCl₃ / a) 0 deg C, 1 h, b) RT, 20 h

5: 85 percent / 1 N NaOH / methanol / a) 0 deg C, 30 min, b) RT, 20 h

6: 90 percent / TFA, HCl / a) 0 deg C, 30 min, b) RT, 30 min

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; chloroform;

DOI:10.1021/jm00142a002

upstream raw materials:

N-(tert-butyloxycarbonyl)-L-tyrosyl-O-tert-butyl-D-serylglycyl-L-phenylalanyl-L-leucyl-O-tert-butyl-L-threonine

Boc-Tyr-OH

N-(tert-butyloxycarbonyl)-L-tyrosyl-O-tert-butyl-D-serine

N-(tert-butyloxycarbonyl)-L-tyrosyl-O-tert-butyl-D-serine methyl ester

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