1-Piperidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-
CAS No.:928338-74-3
Molecular Formula:C21H32N2O4
Molecular Weight:376.496
Hs Code.:

Synonyms:

Suppliers and Price of 1-Piperidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)-

There total 12 articles about 1-Piperidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenyl-, 1,1-dimethylethyl ester, (2S,3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 928338-59-4
C₂₈H₃₈N₂O₆S

: 928338-74-3
3-tert-butoxycarbonylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With naphthalene; sodium; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1055/s-2006-956453

Reference yield:

: 1027234-53-2
N-[1-(amino-phenyl-methyl)-allyl]-4-methyl-benzenesulfonamide

: 928338-74-3
3-tert-butoxycarbonylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: CH₂Cl₂ / 12 h / 20 °C

2: H₂ / Rh(acac)(CO)2; biphephos / tetrahydrofuran / 8 h / 65 °C / 3800 Torr

3: 10-camphorsulfonic acid / tetrahydrofuran / 9 h / 20 °C

4: 100 percent / H₂ / palladium on carbon / ethanol / 12 h / 20 °C / 760 Torr

5: 4-(N,N-dimethylamino)pyridine / tetrahydrofuran / 6 h / 20 °C

6: 96 percent / sodium; naphthalene / tetrahydrofuran / 1 h / -78 °C

With dmap; naphthalene; hydrogen; sodium; acetylacetonatodicarbonylrhodium(l); palladium on activated charcoal; (1S)-10-camphorsulfonic acid; 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1055/s-2006-956453

Reference yield:

: 928338-55-0
[1-phenyl-2-(toluene-4-sulfonylamino)-but-3-enyl]-carbamic acid tert-butyl ester

: 928338-74-3
3-tert-butoxycarbonylamino-2-phenyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Rh(acac)(CO)2; biphephos / tetrahydrofuran / 8 h / 65 °C / 3800 Torr

2: 10-camphorsulfonic acid / tetrahydrofuran / 9 h / 20 °C

3: 100 percent / H₂ / palladium on carbon / ethanol / 12 h / 20 °C / 760 Torr

4: 4-(N,N-dimethylamino)pyridine / tetrahydrofuran / 6 h / 20 °C

5: 96 percent / sodium; naphthalene / tetrahydrofuran / 1 h / -78 °C

With dmap; naphthalene; hydrogen; sodium; acetylacetonatodicarbonylrhodium(l); palladium on activated charcoal; (1S)-10-camphorsulfonic acid; 6,6′-[(3,3′-di-tert-butyl-5,5′-dimethoxy-1,1′-biphenyl-2,2′-diyl)bis(oxy)]bis(di-benzo[d,f][1,3,2]dioxaphosphepin); In tetrahydrofuran; ethanol;
DOI:10.1055/s-2006-956453