2-Piperazinone, 1-[(2S)-6-[(diethylamino)methyl]-1,2,3,4-tetrahydro-2-naphthalenyl]-4-[2- (4-fluorophenyl)ethyl]-

Base Information

Chemical Name:2-Piperazinone, 1-[(2S)-6-[(diethylamino)methyl]-1,2,3,4-tetrahydro-2-naphthalenyl]-4-[2- (4-fluorophenyl)ethyl]-
CAS No.:928675-03-0
Molecular Formula:C₂₇H₃₆FN₃O
Molecular Weight:437.601
Hs Code.:

Synonyms:

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Chemical Property of 2-Piperazinone, 1-[(2S)-6-[(diethylamino)methyl]-1,2,3,4-tetrahydro-2-naphthalenyl]-4-[2- (4-fluorophenyl)ethyl]-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Piperazinone, 1-[(2S)-6-[(diethylamino)methyl]-1,2,3,4-tetrahydro-2-naphthalenyl]-4-[2- (4-fluorophenyl)ethyl]-

There total 7 articles about 2-Piperazinone, 1-[(2S)-6-[(diethylamino)methyl]-1,2,3,4-tetrahydro-2-naphthalenyl]-4-[2- (4-fluorophenyl)ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-6-amino-5,6,7,8-tetrahydronaphthalene-2-carbonitrile hydrochloride

: 928675-03-0
1-(6-diethylaminomethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-4-[2-(4-fluoro-phenyl)-ethyl]-piperazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / sodium iodide; ethyldiisopropylamine / acetonitrile; dimethylformamide / 0.5 h / 130 °C / microwave irradiation

2: hydrogen; ammonia / Raney nickel / dimethylformamide; ethanol; H₂O / 16 h / 20 °C

3: sodium cyanoborohydride; acetic acid / methanol / 0.25 h

With ammonia; hydrogen; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium iodide; nickel; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2006.12.028

Reference yield:

: 1021102-80-6
[2-(4-fluoro-phenyl)-ethylamino]-acetic acid methyl ester

: 928675-03-0
1-(6-diethylaminomethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-4-[2-(4-fluoro-phenyl)-ethyl]-piperazin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; sodium triacetoxyborohydride / methanol; H₂O

2: 66 percent / sodium iodide; ethyldiisopropylamine / acetonitrile; dimethylformamide / 0.5 h / 130 °C / microwave irradiation

3: hydrogen; ammonia / Raney nickel / dimethylformamide; ethanol; H₂O / 16 h / 20 °C

4: sodium cyanoborohydride; acetic acid / methanol / 0.25 h

With ammonia; hydrogen; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium iodide; nickel; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2006.12.028

Reference yield:

: 928675-16-5
{(2-chloro-ethyl)-[2-(4-fluoro-phenyl)-ethyl]-amino}-acetic acid methyl ester

: 928675-03-0
1-(6-diethylaminomethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-4-[2-(4-fluoro-phenyl)-ethyl]-piperazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / sodium iodide; ethyldiisopropylamine / acetonitrile; dimethylformamide / 0.5 h / 130 °C / microwave irradiation

2: hydrogen; ammonia / Raney nickel / dimethylformamide; ethanol; H₂O / 16 h / 20 °C

3: sodium cyanoborohydride; acetic acid / methanol / 0.25 h

With ammonia; hydrogen; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium iodide; nickel; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2006.12.028