Sdz ser-082

Base Information

• Chemical Name: Sdz ser-082
• CAS No.: 141474-54-6
• Molecular Formula: C₁₅H₂₀N₂
• Molecular Weight: 228.337
• UNII: M7FHF24Q22
• DSSTox Substance ID: DTXSID001028477
• Nikkaji Number: J647.976F
• Wikipedia: SDZ_SER-082
• Wikidata: Q44814
• Pharos Ligand ID: WKH3YD9VRZ74
• ChEMBL ID: CHEMBL316069
• Mol file: 141474-54-6.mol

Synonyms:SDZ SER-082;SDZ-SER-082;M7FHF24Q22;UNII-M7FHF24Q22;(+)-cis 4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo(1,7-bc)(2,6)-naphthyridine;7H-Indolo(1,7-bc)(2,6)naphthyridine, 4,5,7a,8,9,10,11,11a-octahydro-10-methyl-, cis-(+)-;141474-59-1;Biomol-NT_000136;D0Z4QC;GTPL195;BPBio1_000024;CHEMBL316069;SCHEMBL13073064;BDBM85099;SER-082;DTXSID001028477;AKOS040745361;CAS_141474-54-6;Q44814;BRD-K31339597-001-01-7;BRD-K31339597-051-01-2

Chemical Property of Sdz ser-082

Chemical Property:

• Vapor Pressure: 1.96E-13mmHg at 25°C
• Boiling Point: 561.2°Cat760mmHg
• Flash Point: 293.2°C
• PSA: 81.08000
• Density: g/cm³
• LogP: 1.81270
• Storage Temp.: Store at RT
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 228.162648646
• Heavy Atom Count: 17
• Complexity: 303

Purity/Quality:

98%min ^*data from raw suppliers

SDZSER082 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC2CN3CCC4=C3C(=CC=C4)C2C1
• Isomeric SMILES: CN1CC[C@@H]2CN3CCC4=C3C(=CC=C4)[C@@H]2C1
• Uses: SDZ SER 082 is a 5-HT2C and 5-HT2B receptor antagonist. SDZ SER 082 Fumarate is a serotonin 2C receptor antagonist.

Technology Process of Sdz ser-082

There total 14 articles about Sdz ser-082 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dihydro-1-<(1,2,3,6-tetrahydro-1-methyl-4-pyridyl)carbonyl>-1H-indole (141474-75-1) → (-)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo<1,7-bc><2,6>naphthyridine (141474-54-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 68 percent / Et(iPr)2N / toluene / 17 h / 80 °C

2: 44 percent / toluene / 12 h / Irradiation

3: 1.) LiAlH₄, conc. H₂SO₄, 2.) 30percent aq. NaOH / 1.) THF, RT, 2 h, 2.) toluene, 30 min

With sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; N-ethyl-N,N-diisopropylamine; In toluene;

DOI:10.1021/jm00001a007

Reference yield:

2,3-dihydro-1-<(1,2,3,6-tetrahydro-1-methyl-4-pyridyl)carbonyl>-1H-indole (141474-75-1) → (+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo<1,7-bc><2,6>naphthyridine (141474-54-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 68 percent / Et(iPr)2N / toluene / 17 h / 80 °C

2: 44 percent / toluene / 12 h / Irradiation

3: 1.) LiAlH₄, conc. H₂SO₄, 2.) 30percent aq. NaOH / 1.) THF, RT, 2 h, 2.) toluene, 30 min

With sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; N-ethyl-N,N-diisopropylamine; In toluene;

DOI:10.1021/jm00001a007

Reference yield:

2,3-dihydro-1-<(1,2,3,6-tetrahydro-1-methyl-4-pyridyl)carbonyl>-1H-indole (141474-75-1) → cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo<1,7-bc><2,6>naphthyridine (141474-54-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / Et(iPr)2N / toluene / 17 h / 80 °C

2: 44 percent / toluene / 12 h / Irradiation

3: 1.) LiAlH₄, conc. H₂SO₄, 2.) 30percent aq. NaOH / 1.) THF, RT, 2 h, 2.) toluene, 30 min

With sodium hydroxide; lithium aluminium tetrahydride; sulfuric acid; N-ethyl-N,N-diisopropylamine; In toluene;

DOI:10.1021/jm00001a007

upstream raw materials:

2,3-dihydro-1-<(1,2,3,6-tetrahydro-1-methyl-4-pyridyl)carbonyl>-1H-indole

<4-<(2,3-dihydro-1H-indol-1-yl)carbonyl>-1,2,3,6-tetrahydro-1-pyridino>carbamic acid ethyl ester

Refernces