3-Aminopropylphosphinic acid

Base Information

• Chemical Name: 3-Aminopropylphosphinic acid
• CAS No.: 103680-47-3
• Molecular Formula: C3H10 N O2 P
• Molecular Weight: 123.09
• UNII: QMT5SS3QRE
• DSSTox Substance ID: DTXSID201336775
• Wikipedia: 3-APPA
• Wikidata: Q27073721,Q106232519
• Pharos Ligand ID: 1XDQWYPTGD3Q
• ChEMBL ID: CHEMBL112203
• Mol file: 103680-47-3.mol

Synonyms:3-aminopropanephosphinic acid;3-aminopropylphosphinic acid;3-aminopropylphosphonous acid;CGP 27 492;CGP 27492;CGP-27492

Chemical Property of 3-Aminopropylphosphinic acid

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 95.92000
• Density: g/cm³
• LogP: -0.20870
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 122.03709053
• Heavy Atom Count: 7
• Complexity: 66

Purity/Quality:

99%min ^*data from raw suppliers

3-AMINO-PROPYLPHOSPHINIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CN)C[P+](=O)O

Technology Process of 3-Aminopropylphosphinic acid

There total 4 articles about 3-Aminopropylphosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

1-amino-2-propene (107-11-9,30551-89-4) → 3-aminopropylphosphinic acid (103680-47-3)

Guidance literature:

With sodium hypophosphite; air; triethyl borane; acetic acid; In methanol; hexane; at 20 ℃; for 2h;

DOI:10.1021/jo015876i

Reference yield: 42.0%

allylamine acetate → 3-aminopropylphosphinic acid (103680-47-3)

Guidance literature:

With sodium hypophosphite; air; triethyl borane; isobutyric Acid; In methanol; at 20 ℃; for 2h;

DOI:10.1016/j.jorganchem.2004.10.005

Reference yield:

(3-benzyloxycarbonylamino-propyl)-H-phosphinic acid . → 3-aminopropylphosphinic acid (103680-47-3)

Guidance literature:

With hydrogenchloride; In water; for 3h; Reflux; Inert atmosphere;

DOI:10.1134/S1068162016060042

upstream raw materials:

3-aminopropyl(diethoxymethyl)-phosphinic acid ethyl ester

1-amino-2-propene

Refernces

• 1、 Gelat, Fabien,Roger, Maxime,Penverne, Christophe,Mazzad, Ahmed,Rolando, Christian,Chausset-Boissarie, La?titia. "UV-mediated hydrophosphinylation of unactivated alkenes with phosphinates under batch and flow conditions". . p. 8385 - 8392. Retrieved 2018/03/09.
• 2、 Queffelec, Clemence,Ribiere, Patrice,Montchamp, Jean-Luc. "Synthesis of P,N-heterocycles from ω-amino-H-phosphinates: Conformationally restricted α-amino acid analogs". scheme or table. p. 8987 - 8991. Retrieved 2009/04/11.