1-(5'-phospho-beta-D-ribofuranosyl)barbituric acid

Base Information

Chemical Name:1-(5'-phospho-beta-D-ribofuranosyl)barbituric acid
CAS No.:29741-00-2
Molecular Formula:C₉H₁₃N₂O₁₀P
Molecular Weight:340.183
Hs Code.:
Mol file:29741-00-2.mol

Synonyms:Barbituricacid, 1-b-D-ribofuranosyl-, 5'-(dihydrogenphosphate) (8CI); 6-Hydroxyuridine 5'-monophosphate; Barbituric acid ribonucleoside5'-phosphate

Suppliers and Price of 1-(5'-phospho-beta-D-ribofuranosyl)barbituric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1-(5'-phospho-beta-D-ribofuranosyl)barbituric acid

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：201.61000
Density:2.015g/cm³
LogP:-2.61700

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(5'-phospho-beta-D-ribofuranosyl)barbituric acid

There total 3 articles about 1-(5'-phospho-beta-D-ribofuranosyl)barbituric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19556-63-9
1-β-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione

: 29741-00-2
1-β-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione 5'-monophosphate

Guidance literature:: 1-β-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione; With trimethyl phosphite; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate; at 0 - 4 ℃;

With triethylammonium hydrogen bicarbonate buffer; at 20 ℃; for 1h; pH=7.4 - 7.6;
DOI:10.1021/jm060848j

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 29741-00-2
1-β-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione 5'-monophosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: SnCl₄ / 1,2-dichloro-ethane / 5 h / 20 °C

1.2: 71 percent / aq. NaHCO₃ / 1,2-dichloro-ethane

2.1: 75 percent / NaOCH₃ / methanol / 3 h / 20 °C

3.1: (OCH₃)3PO; POCl₃; 1,8-bis(dimethylamino)naphthalene / 0 - 4 °C

3.2: aq. triethylammonium hydrogen bicarbonate buffer / 1 h / 20 °C / pH 7.4 - 7.6

With trimethyl phosphite; sodium methylate; tin(IV) chloride; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm060848j

Reference yield:

: 75922-07-5
1-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)(3H)pyrimidine-2,4,6-trione

: 29741-00-2
1-β-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione 5'-monophosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 75 percent / NaOCH₃ / methanol / 3 h / 20 °C

2.1: (OCH₃)3PO; POCl₃; 1,8-bis(dimethylamino)naphthalene / 0 - 4 °C

2.2: aq. triethylammonium hydrogen bicarbonate buffer / 1 h / 20 °C / pH 7.4 - 7.6

With trimethyl phosphite; sodium methylate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; trichlorophosphate; In methanol;
DOI:10.1021/jm060848j