Technology Process of 2H-Pyran,
2-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]tetrahydro-6-methyl-,
(2S,6S)-
There total 10 articles about 2H-Pyran,
2-[2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]ethyl]tetrahydro-6-methyl-,
(2S,6S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C26H37O4SiSO2CH3;
With
potassium carbonate;
In
methanol;
at 20 ℃;
for 16h;
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 100 ℃;
for 12h;
Further stages.;
DOI:10.1271/bbb.70.712
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 97 percent / aq. KOH / ethanol / 1 h / 0 °C
2.1: pivaloyl chloride; Et3N / tetrahydrofuran / 1 h / 0 °C
2.2: 95 percent / tetrahydrofuran / 1 h / 0 °C
3.1: KHMDS / tetrahydrofuran; toluene / 0.5 h / -75 °C
3.2: 53 percent / MoO5*Py*HMPA / tetrahydrofuran; toluene / 2 h / -75 °C
4.1: 89 percent / LiBH4 / methanol; tetrahydrofuran / 2 h / 0 °C
5.1: pyridine / CH2Cl2 / 5 h / 0 °C
6.1: 3.52 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
7.1: 99 percent / 4-DMAP; pyridine / 1 h / 20 °C
8.1: 88 percent / TMSBr / CH2Cl2 / 2 h / -10 °C
9.1: Et3N / CH2Cl2 / 1 h / 20 °C
10.1: K2CO3 / methanol / 16 h / 20 °C
10.2: 1.68 g / K2CO3 / dimethylformamide / 12 h / 100 °C
With
pyridine; dmap; potassium hydroxide; lithium aluminium tetrahydride; lithium borohydride; trimethylsilyl bromide; pivaloyl chloride; potassium hexamethylsilazane; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;
DOI:10.1271/bbb.70.712
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: KHMDS / tetrahydrofuran; toluene / 0.5 h / -75 °C
1.2: 53 percent / MoO5*Py*HMPA / tetrahydrofuran; toluene / 2 h / -75 °C
2.1: 89 percent / LiBH4 / methanol; tetrahydrofuran / 2 h / 0 °C
3.1: pyridine / CH2Cl2 / 5 h / 0 °C
4.1: 3.52 g / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
5.1: 99 percent / 4-DMAP; pyridine / 1 h / 20 °C
6.1: 88 percent / TMSBr / CH2Cl2 / 2 h / -10 °C
7.1: Et3N / CH2Cl2 / 1 h / 20 °C
8.1: K2CO3 / methanol / 16 h / 20 °C
8.2: 1.68 g / K2CO3 / dimethylformamide / 12 h / 100 °C
With
pyridine; dmap; lithium aluminium tetrahydride; lithium borohydride; trimethylsilyl bromide; potassium hexamethylsilazane; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1271/bbb.70.712
