2-Naphthol, 6-bromo-1-methyl-

Base Information

• Chemical Name: 2-Naphthol, 6-bromo-1-methyl-
• CAS No.: 16667-01-9
• Molecular Formula: C11H9 Br O
• Molecular Weight: 237.096
• DSSTox Substance ID: DTXSID20168151
• Nikkaji Number: J2.806.322I
• Mol file: 16667-01-9.mol

Synonyms:1-Methyl-6-bromo-2-naphthol;BRN 3243936;2-NAPHTHOL, 6-BROMO-1-METHYL-;16667-01-9;3-06-00-03020 (Beilstein Handbook Reference);6-Bromo-1-methyl-2-naphthol;SCHEMBL5343236;DTXSID20168151;YNZVWWALVATSDE-UHFFFAOYSA-N;1-Methyl-6-bromonaphthalene-2-ol;LS-95417

Chemical Property of 2-Naphthol, 6-bromo-1-methyl-

Chemical Property:

• Vapor Pressure: 1.12E-05mmHg at 25°C
• Boiling Point: 359.8°Cat760mmHg
• Flash Point: 171.4°C
• Density: 1.535g/cm³
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 235.98368
• Heavy Atom Count: 13
• Complexity: 183

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC2=C1C=CC(=C2)Br)O

Technology Process of 2-Naphthol, 6-bromo-1-methyl-

There total 24 articles about 2-Naphthol, 6-bromo-1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-methyl-2-naphthol (1076-26-2) → 6-bromo-1-methyl-2-naphthol (16667-01-9)

Guidance literature:

With bromine; acetic acid; at 10 - 20 ℃; for 0.25h;

DOI:10.1016/j.bmc.2011.01.017

Reference yield: 96.0%

6-bromo-2-methoxy-1-methyl naphthalene (247174-14-7) → 6-bromo-1-methyl-2-naphthol (16667-01-9)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

C15H16BrNO2 (739360-70-4) → 6-bromo-1-methyl-2-naphthol (16667-01-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 3h; Reflux;

DOI:10.1016/j.bmc.2013.12.056

upstream raw materials:

1-methyl-2-naphthol

1-bromo-1-methylnaphthalen-2(1H)-one

N-(6-bromo-1-methyl-2-oxo-1,2-dihydro-[1]naphthyl)-N-phenyl-acetamide

6-bromo-1-(2,4-dibromo-anilino)-1-methyl-1H-naphthalen-2-one

Downstream raw materials:

4-bromophthalic acid

1-(6-{[tert-butyl(dimethyl)silyl]oxy}-5-methyl-2-naphthyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propan-1-ol

6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-1-methyl-2-naphthol

6-[1-Hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-propyl)-1-methyl-2-naphthyl Trifluoromethanesulfonate

Refernces

• 1、 -. "(PIPERIDIN-3-YL)(NAPHTHALEN-2-YL)METHANONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HISTONE DEMETHYLASE KDM2B FOR THE TREATMENT OF CANCER". Page/Page column 87. . Retrieved 2016/08/10.
• 2、 Kaku, Tomohiro,Matsunaga, Nobuyuki,Ojida, Akio,Tanaka, Toshimasa,Hara, Takahito,Yamaoka, Masuo,Kusaka, Masami,Tasaka, Akihiro. "17,20-Lyase inhibitors. Part 4: Design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors". experimental part. p. 1751 - 1770. Retrieved 2011/04/17.