Dexamethasone isonicotinate

Base Information

Chemical Name:Dexamethasone isonicotinate
CAS No.:2265-64-7
Deprecated CAS:68402-70-0
Molecular Formula:C₂₈H₃₂FNO₆
Molecular Weight:497.564
Hs Code.:
European Community (EC) Number:218-866-5
UNII:8LGC0BOA71
DSSTox Substance ID:DTXSID3057690
Nikkaji Number:J15.020G
Wikipedia:Dexamethasone_isonicotinate
Wikidata:Q5268313
NCI Thesaurus Code:C77418
Metabolomics Workbench ID:152673
ChEMBL ID:CHEMBL3186453
Mol file:2265-64-7.mol

Synonyms:Auxison;Dexamethasone Isonicotinate;HE 111;HE-111;HE111;Isonicotinate, Dexamethasone

Suppliers and Price of Dexamethasone isonicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Dexamethasone isonicotinate European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Dexamethasone isonicotinate for impurity C identification European Pharmacopoeia (EP) Reference Standard
y0000511
$ 190.00

Sigma-Aldrich
Dexamethasone isonicotinate European Pharmacopoeia (EP) Reference Standard
y0000538
$ 190.00

American Custom Chemicals Corporation
DEXAMETHASONE-21-ISONICOTINATE 95.00%
1G
$ 633.66

Total 46 raw suppliers

Chemical Property of Dexamethasone isonicotinate

Chemical Property:

Vapor Pressure:3.39E-19mmHg at 25°C
Melting Point:256°C
Refractive Index:1.608
Boiling Point:676 °C at 760 mmHg
PKA:11.92±0.70(Predicted)
Flash Point:362.6 °C
PSA：113.79000
Density:1.34 g/cm³
LogP:3.15540
Storage Temp.:2-8°C
Solubility.:Practically insoluble in water, slightly soluble in anhydrous ethanol and in acetone.
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:497.22136590
Heavy Atom Count:36
Complexity:1040

Purity/Quality:

99% ^*data from raw suppliers

Dexamethasone isonicotinate European Pharmacopoeia (EP) Reference Standard ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C5=CC=NC=C5)O)C)O)F)C
Isomeric SMILES:C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C5=CC=NC=C5)O)C)O)F)C
Recent EU Clinical Trials:Efficacy and Safety of Corti Biciron N versus Dexa-Gentamicinin the treatment of external ocular inflammation in which the application of antibiotics is advisableA multicentre, randomised, single-blind, active-controlled, parallel-group, phase III pilot study
Uses Dexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, topically, and parenterally. Its unintended mineralocorticoid action may cause salt and water retention.

Technology Process of Dexamethasone isonicotinate

There total 2 articles about Dexamethasone isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: