Milbemycin D

Base Information

Chemical Name:Milbemycin D
CAS No.:77855-81-3
Molecular Formula:C₃₃H₄₈O₇
Molecular Weight:556.74
Hs Code.:
UNII:04S0E2XJQI
Wikidata:Q27247671
Mol file:77855-81-3.mol

Synonyms:5-hydroxymilbemycin beta7;CL 301,423;CL 301423;Cydectin;Milbeknock;milbemectin;milbemycin A3;milbemycin A4;milbemycin alpha1;milbemycin alpha10;milbemycin alpha11;milbemycin alpha13;milbemycin alpha14;milbemycin alpha15;milbemycin alpha2;milbemycin alpha3;milbemycin alpha4;milbemycin alpha5;milbemycin alpha6;milbemycin alpha7;milbemycin alpha8;milbemycin alpha9;milbemycin B;milbemycin beta1;milbemycin beta12;milbemycin beta2;milbemycin beta3;milbemycin D;milbemycins;mixture of milbemycins A3 and A4;moxidectin

Suppliers and Price of Milbemycin D

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Milbemycin D
1mg
$ 593.00

TRC
MilbemycinD
0.5mg
$ 435.00

Cayman Chemical
Milbemycin D ≥95%
5mg
$ 1196.00

Cayman Chemical
Milbemycin D ≥95%
1mg
$ 319.00

American Custom Chemicals Corporation
MILBEMYCIN D 95.00%
5MG
$ 502.15

Total 15 raw suppliers

Chemical Property of Milbemycin D

Chemical Property:

Vapor Pressure:5.55E-25mmHg at 25°C
Melting Point:186-188°
Refractive Index:1.5300 (estimate)
Boiling Point:735.7°C at 760 mmHg
Flash Point:231.9°C
PSA：94.45000
Density:1.18g/cm³
LogP:5.17030
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly)
XLogP3:4.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:556.34000387
Heavy Atom Count:40
Complexity:1090

Purity/Quality:

98%Min ^*data from raw suppliers

Milbemycin D ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CCC2(CC3CC(O2)CC=C(CC(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)C)OC1C(C)C
Isomeric SMILES:C[C@H]1CC[C@]2(C[C@@H]3C[C@H](O2)C/C=C(/C[C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)\C)O[C@@H]1C(C)C
Uses Milbemycins are a complex family of macrocyclic lactones containing a highly characteristic spiroketal group, produced by Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycin D is a minor member of a group of analogues containing a 25-isopropyl substituent. Milbemycin D is a highly selective and potent nematocide and insecticide. Like the closely related avermectin, milbemycins are thought to act on chloride-gated ion channels. Milbemycin D (Milbemycin EP Impurity C) is a macrocyclic lactones that can be used as a nematocide and insecticide.

Technology Process of Milbemycin D

There total 17 articles about Milbemycin D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 87616-38-4,105454-62-4
5-oxo-5-deoxymilbemycin D

: 77855-81-3
milbemycin D

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.166667h;
DOI:10.1021/ja961071u

Reference yield:

: 179917-79-4
C₃₃H₅₀O₇

: 77855-81-3
milbemycin D

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / Pr₄NRuO₄, NMO, 4 Angstroem molecular sieves / CH₂Cl₂ / 4 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 8 h / 0 °C

3: 0.023 g / CH₂Cl₂ / 1 h / -78 °C

4: 66 percent / aq. 48percent HF, pyridine / acetonitrile / 24 h / Ambient temperature

5: NaIO₄ / tetrahydrofuran; H₂O / 2 h / Ambient temperature

6: 32 percent / NaBH₄ / methanol / 0.17 h / 0 °C

With pyridine; sodium tetrahydroborate; sodium periodate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen fluoride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ja961071u

Reference yield:

: C₃₃H₄₈O₇

: 77855-81-3
milbemycin D

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 8 h / 0 °C

2: 0.023 g / CH₂Cl₂ / 1 h / -78 °C

3: 66 percent / aq. 48percent HF, pyridine / acetonitrile / 24 h / Ambient temperature

4: NaIO₄ / tetrahydrofuran; H₂O / 2 h / Ambient temperature

5: 32 percent / NaBH₄ / methanol / 0.17 h / 0 °C

With pyridine; sodium tetrahydroborate; sodium periodate; hydrogen fluoride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ja961071u