2-Thiophenecarboxylic acid, 5-[[2-amino-5-[(2,2-dimethyl-1-oxopropoxy)methyl]phenyl]amino]-3-[(1R )-1-(2-chlorophenyl)ethoxy]-, methyl ester

Base Information

• Chemical Name: 2-Thiophenecarboxylic acid, 5-[[2-amino-5-[(2,2-dimethyl-1-oxopropoxy)methyl]phenyl]amino]-3-[(1R )-1-(2-chlorophenyl)ethoxy]-, methyl ester
• CAS No.: 929095-61-4
• Molecular Formula: C26H29ClN2O5S
• Molecular Weight: 517.046
• Mol file: 929095-61-4.mol

Synonyms:

Chemical Property of 2-Thiophenecarboxylic acid, 5-[[2-amino-5-[(2,2-dimethyl-1-oxopropoxy)methyl]phenyl]amino]-3-[(1R )-1-(2-chlorophenyl)ethoxy]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Thiophenecarboxylic acid, 5-[[2-amino-5-[(2,2-dimethyl-1-oxopropoxy)methyl]phenyl]amino]-3-[(1R )-1-(2-chlorophenyl)ethoxy]-, methyl ester

There total 6 articles about 2-Thiophenecarboxylic acid, 5-[[2-amino-5-[(2,2-dimethyl-1-oxopropoxy)methyl]phenyl]amino]-3-[(1R )-1-(2-chlorophenyl)ethoxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[(5-{[(2,2-dimethylpropanoyl)oxy]methyl}-2-nitrophenyl)amino]-2-thiophenecarboxylate (929095-60-3) → methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}-phenyl)amino]-3-{[(7R)-7-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxylate (929095-61-4)

Guidance literature:

With hydrogen; 5 wt% sulfided platinum on carbon; In ethyl acetate; at 20 ℃; for 3h; under 2585.81 Torr;

Reference yield:

3-hydroxy-4-nitrobenzyl pivalate (929095-34-1) → methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}-phenyl)amino]-3-{[(7R)-7-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxylate (929095-61-4)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 20 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 0.5 h / 60 °C

3: hydrogen / 5 % platinum on sulfided carbon / ethyl acetate / 3 h / 2585.81 Torr

With hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5 % platinum on sulfided carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; ethyl acetate; toluene;

Reference yield:

4-nitro-3-{[(trifluoromethyl)sulfonyl]oxy}benzyl pivalate (929095-35-2) → methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}-phenyl)amino]-3-{[(7R)-7-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxylate (929095-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 0.5 h / 60 °C

2: hydrogen / 5 % platinum on sulfided carbon / ethyl acetate / 3 h / 2585.81 Torr

With hydrogen; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5 % platinum on sulfided carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethyl acetate; toluene;

upstream raw materials:

methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[(5-{[(2,2-dimethylpropanoyl)oxy]methyl}-2-nitrophenyl)amino]-2-thiophenecarboxylate

3-hydroxy-4-nitrobenzyl pivalate

4-nitro-3-{[(trifluoromethyl)sulfonyl]oxy}benzyl pivalate

3-hydroxy-4-nitro-benzoic acid