3,3-difluoro-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

Base Information

Chemical Name:3,3-difluoro-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
CAS No.:72114-97-7
Molecular Formula:C₁₁H₉F₅N₂O₄
Molecular Weight:328.195
Hs Code.:
ChEMBL ID:CHEMBL140851
DSSTox Substance ID:DTXSID10564002
Nikkaji Number:J360.283D

Synonyms:72114-97-7;3,3-difluoro-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide;CHEMBL140851;DTXSID10564002

Suppliers and Price of 3,3-difluoro-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3,3-difluoro-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:3
Exact Mass:328.04824758
Heavy Atom Count:22
Complexity:439

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(F)F)(C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F)O

Technology Process of 3,3-difluoro-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

There total 1 articles about 3,3-difluoro-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1869-40-5
2-(difluoromethyl)-2-hydroxypropionic acid

: 393-11-3
4-nitro-3-(trifluoromethyl)benzeneamine

: 72114-97-7
3,3-Difluoro-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide

Guidance literature:: With thionyl chloride; ISOPROPYLAMIDE; Yield given. Multistep reaction; 1.) from -20 to -10 deg C, 30 min, 2.) RT, 3 h;
DOI:10.1021/jm00105a067