3-[(Tetrahydro-2H-pyran-4-yl)oxy]benzenaMine HCl

Base Information

• Chemical Name: 3-[(Tetrahydro-2H-pyran-4-yl)oxy]benzenaMine HCl
• CAS No.: 929194-97-8
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Mol file: 929194-97-8.mol

Synonyms:

Chemical Property of 3-[(Tetrahydro-2H-pyran-4-yl)oxy]benzenaMine HCl

Chemical Property:

• PSA: 44.48000
• LogP: 2.40780

Purity/Quality:

98% ^*data from raw suppliers

3-[(Tetrahydro-2H-pyran-4-yl)oxy]benzenamineHCl 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[(Tetrahydro-2H-pyran-4-yl)oxy]benzenaMine HCl

There total 3 articles about 3-[(Tetrahydro-2H-pyran-4-yl)oxy]benzenaMine HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(3-nitrophenoxy)tetrahydro-2H-pyran (929194-94-5) → 3-(tetrahydro-2H-pyran-4-yloxy)aniline (929194-97-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.bmcl.2006.10.088

Reference yield: 72.0%

→ 3-(tetrahydro-2H-pyran-4-yloxy)aniline (929194-97-8)

Guidance literature:

With methanol; sodium tetrahydroborate; In water; at 35 ℃; for 0.0833333h;

Reference yield:

4-bromotetrahydro-2H-pyran (25637-16-5) + meta-nitrophenol (554-84-7) → 3-(tetrahydro-2H-pyran-4-yloxy)aniline (929194-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 100 °C / Sealed tube

2: hydrogen / palladium 10% on activated carbon / ethyl acetate

With hydrogen; caesium carbonate; palladium 10% on activated carbon; In ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

4-(3-nitrophenoxy)tetrahydro-2H-pyran

4-bromotetrahydro-2H-pyran

meta-nitrophenol

Downstream raw materials:

C₁₂H₁₃NO₃

Refernces

• 1、 -. "BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS". Page/Page column 128. . Retrieved 2012/05/20.