2-{3-chloro-4-[(4-chlorophenyl)(hydroxy)methyl]phenyl}-1,2,4-triazine-3,5(2H,4H)-dione

Base Information

Chemical Name:2-{3-chloro-4-[(4-chlorophenyl)(hydroxy)methyl]phenyl}-1,2,4-triazine-3,5(2H,4H)-dione
CAS No.:38561-06-7
Molecular Formula:C16H11Cl2N3O3
Molecular Weight:364.1828
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{3-chloro-4-[(4-chlorophenyl)(hydroxy)methyl]phenyl}-1,2,4-triazine-3,5(2H,4H)-dione

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.54g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 2-{3-chloro-4-[(4-chlorophenyl)(hydroxy)methyl]phenyl}-1,2,4-triazine-3,5(2H,4H)-dione

There total 9 articles about 2-{3-chloro-4-[(4-chlorophenyl)(hydroxy)methyl]phenyl}-1,2,4-triazine-3,5(2H,4H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 38571-19-6
2-<3-chloro-4-(4-chlorobenzoyl)phenyl>-1,2,4-triazine-3,5(2H,4H)-dione

: 38561-06-7
2-{3-chloro-4-[(4-chloro-phenyl)-hydroxy-methyl]-phenyl}-2H-[1,2,4]triazine-3,5-dione

Guidance literature:: With sodium hydroxide; sodium tetrahydroborate; In water; for 18h;
DOI:10.1021/jm00355a019

Reference yield:

: 50274-64-1
(2-chloro-4-nitrophenyl)(4-chlorophenyl)-methanone

: 38561-06-7
2-{3-chloro-4-[(4-chloro-phenyl)-hydroxy-methyl]-phenyl}-2H-[1,2,4]triazine-3,5-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 25 °C / 2068.6 - 5171.5 Torr

2: 1.) conc. HCl, NaNO₂, 2.) NaOAc / 1.) HOAc, H₂O, 10 deg C, 30 min, 2.) HOAc, H₂O, RT, 1 h

3: NaOAc / acetic acid; H₂O / 2 h / 106 °C

4: 50percent H₂SO₄ / acetic acid; H₂O / 2 h / Heating

5: 71 percent / mercaptoacetic acid / propionic acid / 1.3 h / 170 °C

6: 88 percent / 10percent aq. NaOH, NaBH₄ / H₂O / 18 h

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; sulfuric acid; hydrogen; sodium acetate; mercaptoacetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; water; acetic acid; propionic acid;
DOI:10.1021/jm00355a019

Reference yield:

: 7073-36-1
2-chloro-4-nitrobenzoyl chloride

: 38561-06-7
2-{3-chloro-4-[(4-chloro-phenyl)-hydroxy-methyl]-phenyl}-2H-[1,2,4]triazine-3,5-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 83.5 percent / AlCl₃ / CHCl₃ / a) RT, overnight, b) reflux, 1 h

2: 70 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 25 °C / 2068.6 - 5171.5 Torr

3: 1.) conc. HCl, NaNO₂, 2.) NaOAc / 1.) HOAc, H₂O, 10 deg C, 30 min, 2.) HOAc, H₂O, RT, 1 h

4: NaOAc / acetic acid; H₂O / 2 h / 106 °C

5: 50percent H₂SO₄ / acetic acid; H₂O / 2 h / Heating

6: 71 percent / mercaptoacetic acid / propionic acid / 1.3 h / 170 °C

7: 88 percent / 10percent aq. NaOH, NaBH₄ / H₂O / 18 h

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; sulfuric acid; hydrogen; sodium acetate; mercaptoacetic acid; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; chloroform; water; acetic acid; propionic acid;
DOI:10.1021/jm00355a019