Bavisant

Base Information

Chemical Name:Bavisant
CAS No.:929622-08-2
Molecular Formula:C19H27N3O2
Molecular Weight:329.442
Hs Code.:
UNII:9827P7LFVH
ChEMBL ID:CHEMBL2103862
DSSTox Substance ID:DTXSID001026045
Metabolomics Workbench ID:153313
NCI Thesaurus Code:C171762
Pharos Ligand ID:2RSYCSS9VM56
Wikidata:Q27272071
Mol file:929622-08-2.mol

Synonyms:bavisant;JNJ-31001074

Suppliers and Price of Bavisant

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Bavisant 98+%
10mg
$ 247.00

Crysdot
Bavisant 98+%
5mg
$ 163.00

Crysdot
Bavisant 98+%
100mg
$ 911.00

Crysdot
Bavisant 98+%
50mg
$ 586.00

American Custom Chemicals Corporation
BAVISANT 95.00%
5MG
$ 502.70

Total 4 raw suppliers

Chemical Property of Bavisant

Chemical Property:

Boiling Point:485.2±45.0 °C(Predicted)
PKA:7.66±0.70(Predicted)
PSA：36.02000
Density:1.220±0.06 g/cm3(Predicted)
LogP:1.25270
XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:329.21032711
Heavy Atom Count:24
Complexity:418

Purity/Quality:

99%, ^*data from raw suppliers

Bavisant 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1N2CCN(CC2)C(=O)C3=CC=C(C=C3)CN4CCOCC4
Recent ClinicalTrials:A Study to Evaluate the Pharmacokinetic Drug Interaction Between Multiple Doses of JNJ-31001074 and a Single Dose of an Oral Contraceptive Containing Ethinyl Estradiol and Levonorgestrel in Women
Recent EU Clinical Trials:Dose finding phase IIb study of Bavisant to evaluate its safety and efficacy in treatment of excessive daytime sleepiness (EDS) in parkinson’s Disease (PD).

Technology Process of Bavisant

There total 9 articles about Bavisant which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 110-91-8,99108-56-2
morpholine

: 929622-21-9
4-(4-cyclopropyl-piperazine-1-carbonyl)-benzaldehyde

: 929622-08-2
Bavisant

Guidance literature:: morpholine; 4-(4-cyclopropyl-piperazine-1-carbonyl)-benzaldehyde; In 1,2-dichloro-ethane; for 0.0833333h;

In 1,2-dichloro-ethane; at 10 - 20 ℃; for 21h;

With sodium hydroxide; water; more than 3 stages; Product distribution / selectivity;

Reference yield: 38.0%

: 929622-20-8
(4-morpholin-4-ylmethylphenyl)piperazin-1-yl-methanone

: 27374-25-0
[(1-Ethoxycyclopropyl)oxy]trimethylsilane

: 929622-08-2
Bavisant

Guidance literature:: (4-morpholin-4-ylmethylphenyl)piperazin-1-yl-methanone; [(1-Ethoxycyclopropyl)oxy]trimethylsilane; With sodium cyanoborohydride; acetic acid; In methanol; at 60 ℃; for 18h;

With sodium hydroxide; In water; Product distribution / selectivity;

Reference yield:

: 1-cyclopropylpiperazine dihydrochloride

: 123742-32-5
4-(4-Morpholinylmethyl)benzoyl chloride

: 929622-08-2
Bavisant

Guidance literature:: 1-cyclopropylpiperazine dihydrochloride; With sodium hydroxide; In water; toluene; at 10 ℃;

4-(4-Morpholinylmethyl)benzoyl chloride; With sodium carbonate; In water; toluene; at 10 ℃; for 2h;