N-benzyl-4-hydroxymethylaniline

Base Information

• Chemical Name: N-benzyl-4-hydroxymethylaniline
• CAS No.: 145153-06-6
• Molecular Formula: C14H15 N O
• Molecular Weight: 213.279
• Hs Code.: 2922199090
• Mol file: 145153-06-6.mol

Synonyms:N-benzyl-4-hydroxymethylaniline

Chemical Property of N-benzyl-4-hydroxymethylaniline

Chemical Property:

• Vapor Pressure: 1.2E-06mmHg at 25°C
• Boiling Point: 385.9°C at 760 mmHg
• Flash Point: 154.5°C
• PSA: 32.26000
• Density: 1.162g/cm³
• LogP: 2.86400

Purity/Quality:

≥99% ^*data from raw suppliers

(4-(Benzylamino)phenyl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-benzyl-4-hydroxymethylaniline

There total 7 articles about N-benzyl-4-hydroxymethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

para-Chlorobenzyl alcohol (873-76-7) + benzylamine (100-46-9) → N-benzyl-4-hydroxymethylaniline (145153-06-6)

Guidance literature:

With potassium phosphate; In dimethyl sulfoxide; at 80 ℃; UV-irradiation;

DOI:10.1007/s11426-020-9859-9

Reference yield: 90.0%

4-iodo-benzyl alcohol (18282-51-4) + benzylamine (100-46-9) → N-benzyl-4-hydroxymethylaniline (145153-06-6)

Guidance literature:

With copper(l) iodide; 1-tetralone oxime; potassium hydroxide; In water; at 25 ℃; for 36h; Sealed tube; Inert atmosphere; Green chemistry;

DOI:10.1039/c7ob02126g

Reference yield: 85.0%

→ N-benzyl-4-hydroxymethylaniline (145153-06-6)

Guidance literature:

With potassium phosphate; copper(l) iodide; N¹,N²-bis(2,4,6-trimethoxyphenyl)oxalamide; In dimethyl sulfoxide; at 120 ℃; for 24h; Inert atmosphere; Schlenk technique;

upstream raw materials:

4-aminobenzenemethanol

benzyl chloride

4-(benzylideneamino)benzyl alcohol

4-nitrobenzyl chloride