Ethyl 2-cyano-2-fluoropropanoate

Base Information

Chemical Name:Ethyl 2-cyano-2-fluoropropanoate
CAS No.:14122-32-8
Molecular Formula:C₆H₈FNO₂
Molecular Weight:145.133
Hs Code.:
NSC Number:84020
DSSTox Substance ID:DTXSID30292597
Nikkaji Number:J529.442H
Mol file:14122-32-8.mol

Synonyms:14122-32-8;ethyl 2-cyano-2-fluoropropanoate;NSC84020;NCIOpen2_000975;SCHEMBL15858335;DTXSID30292597;NSC-84020;ethyl 2-cyano-2-fluoro-2-methylacetate;EN300-6497392

Suppliers and Price of Ethyl 2-cyano-2-fluoropropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Ethyl 2-cyano-2-fluoropropanoate

Chemical Property:

Vapor Pressure:0.693mmHg at 25°C
Boiling Point:185.5°Cat760mmHg
Flash Point:66°C
Density:1.116g/cm³
XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:145.05390666
Heavy Atom Count:10
Complexity:183

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C)(C#N)F

Technology Process of Ethyl 2-cyano-2-fluoropropanoate

There total 2 articles about Ethyl 2-cyano-2-fluoropropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572-99-2
ethyl 2-cyanopropionate

: 14122-32-8
ethyl 2-cyano-2-fluoropropionate

Guidance literature:: Multistep reaction; (i) KOEt, EtOH, (ii) DMF, (iii) ClO₃F;
DOI:10.1021/jm00316a008

Reference yield:

: 617-35-6
2-oxo-propionic acid ethyl ester

: 14122-32-8
ethyl 2-cyano-2-fluoropropionate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 8 h / Heating

2: (diethylamino)sulfur trifluoride / CH₂Cl₂ / 2 h / Ambient temperature

With diethylamino-sulfur trifluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00059a036