2,2-DIMETHYLPROPANETHIOHYDRAZIDE

Base Information

• Chemical Name: 2,2-DIMETHYLPROPANETHIOHYDRAZIDE
• CAS No.: 93114-01-3
• Molecular Formula: C5H12N2S
• Molecular Weight: 132.22700
• Mol file: 93114-01-3.mol

Synonyms:2,2-Dimethyl-thiopropionic acid hydrazide;Thiopivalinsaeure-hydrazid;thiopivaloylhydrazine;

Chemical Property of 2,2-DIMETHYLPROPANETHIOHYDRAZIDE

Chemical Property:

• Melting Point: 93 - 94 °C (petroleum ether)
• PSA: 70.14000
• LogP: 1.91440

Purity/Quality:

99% ^*data from raw suppliers

2,2-DIMETHYLPROPANETHIOHYDRAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-DIMETHYLPROPANETHIOHYDRAZIDE

There total 1 articles about 2,2-DIMETHYLPROPANETHIOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl dithiopivalate (40920-16-9) → 1,1-dimethylethanethioic acid hydrazide (93114-01-3)

Guidance literature:

With hydrazine hydrate; In methanol;

Reference yield: 84.0%

1,1-dimethylethanethioic acid hydrazide (93114-01-3) + benzylglyoxylate (52709-42-9) → benzyl 5-tert-butyl-2,3-dihydro-1,3,4-thiadiazole-2-carboxylate (109684-02-8)

Guidance literature:

In ethanol; for 16h; Ambient temperature;

DOI:10.1021/jm00105a066

Reference yield:

1,1-dimethylethanethioic acid hydrazide (93114-01-3) → utibapril (109683-61-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / ethanol / 16 h / Ambient temperature

2: 0.82 g / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 16 h / Ambient temperature

3: 45 percent / pyrrolidine, 3A molecular sieves / acetonitrile / 6 h / Ambient temperature

4: 53 percent / H₂ / 10percent Pd/C / ethanol / 16 h / Ambient temperature

With pyrrolidine; 3 A molecular sieve; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; acetonitrile;

DOI:10.1021/jm00105a066

upstream raw materials:

methyl dithiopivalate

Downstream raw materials:

Thiopivalinsaeure-benzylidenhydrazid

benzyl 5-tert-butyl-2,3-dihydro-1,3,4-thiadiazole-2-carboxylate

Utibaprilat

utibapril