Technology Process of Acetic acid, [4-[(4-aminophenyl)acetyl]-2,3-dichlorophenoxy]-,
hydrochloride
There total 6 articles about Acetic acid, [4-[(4-aminophenyl)acetyl]-2,3-dichlorophenoxy]-,
hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 65 percent / AlCl3 / CH2Cl2 / 2 h / Heating
2: 66 percent / 48percent HBr / acetic acid / 22 h / Heating
3: 89 percent / p-TsOH / toluene / 19 h / Heating
4: 86 percent / K2CO3 / butan-2-one / 2 h / Heating
5: 1.) H2, 2.) 6N HCl / 1.) Raney Ni / 1.) methyl cellosolve, 2.) H2O, reflux, 20 h
With
hydrogenchloride; aluminium trichloride; hydrogen bromide; hydrogen; potassium carbonate; toluene-4-sulfonic acid;
nickel;
In
dichloromethane; acetic acid; toluene; butanone;
DOI:10.1021/jm00379a016
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 89 percent / p-TsOH / toluene / 19 h / Heating
2: 86 percent / K2CO3 / butan-2-one / 2 h / Heating
3: 1.) H2, 2.) 6N HCl / 1.) Raney Ni / 1.) methyl cellosolve, 2.) H2O, reflux, 20 h
With
hydrogenchloride; hydrogen; potassium carbonate; toluene-4-sulfonic acid;
nickel;
In
toluene; butanone;
DOI:10.1021/jm00379a016
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 66 percent / 48percent HBr / acetic acid / 22 h / Heating
2: 89 percent / p-TsOH / toluene / 19 h / Heating
3: 86 percent / K2CO3 / butan-2-one / 2 h / Heating
4: 1.) H2, 2.) 6N HCl / 1.) Raney Ni / 1.) methyl cellosolve, 2.) H2O, reflux, 20 h
With
hydrogenchloride; hydrogen bromide; hydrogen; potassium carbonate; toluene-4-sulfonic acid;
nickel;
In
acetic acid; toluene; butanone;
DOI:10.1021/jm00379a016
