4,4,4-TRIFLUOROBUTYLAMINE

Base Information

• Chemical Name: 4,4,4-TRIFLUOROBUTYLAMINE
• CAS No.: 819-46-5
• Molecular Formula: C4H8F3N
• Molecular Weight: 127.109
• Hs Code.: 2921199090
• Mol file: 819-46-5.mol

Synonyms:Butylamine,4,4,4-trifluoro- (7CI,8CI);4,4,4-Trifluorobutylamine;4,4,4-Trifluorobutan-1-amine;

Chemical Property of 4,4,4-TRIFLUOROBUTYLAMINE

Chemical Property:

• Vapor Pressure: 148mmHg at 25°C
• Refractive Index: 1.345
• Boiling Point: 67.1 °C at 760 mmHg
• Flash Point: 3.6 °C
• PSA: 26.02000
• Density: 1.108 g/cm³
• LogP: 1.98790

Purity/Quality:

98%Min ^*data from raw suppliers

4,4,4-Trifluorobutylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4,4-TRIFLUOROBUTYLAMINE

There total 6 articles about 4,4,4-TRIFLUOROBUTYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4,4-trifluorobutanol (461-18-7) → 4,4,4-trifluorobutan-1-amine (819-46-5)

Guidance literature:

4,4,4-trifluorobutanol; With iminodicarboxylic acid di-tert-butyl ester; triphenylphosphine; diethylazodicarboxylate; In toluene; at 20 ℃; for 24h;

With trifluoroacetic acid; In toluene; at 0 - 20 ℃; for 24h;

With sodium hydroxide; In water;

Reference yield:

4,4,4-trifluorobutyroamide (461-34-7) → 4,4,4-trifluorobutan-1-amine (819-46-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 12h; Heating;

DOI:10.1021/jm00035a008

Reference yield:

4-azido-1,1,1-trifluorobutane (101055-03-2) → 4,4,4-trifluorobutan-1-amine (819-46-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In diethyl ether; for 12h; Yield given; Ambient temperature;

upstream raw materials:

4-amino-n-butyric acid

4-azido-1,1,1-trifluorobutane

4,4,4-trifluorobutyroamide

4,4,4-trifluorobutanol

Downstream raw materials:

3-Methoxy-4-[1-methyl-5-(4,4,4-trifluoro-butylcarbamoyl)-1H-indol-3-ylmethyl]-benzoic acid methyl ester

4,4,4-trifluorobutan-1-amine hydrochloride

3-nitro-4-(4,4,4-trifluorobutylamino)benzonitrile

4-nitrophenyl 4,4,4-trifluorobutylcarbamate

Refernces

• 1、 -. "NEW COMPOUNDS I/418". Page/Page column 30. . Retrieved 2008/06/13.
• 2、 Romero, F. Anthony,Vodonick, Steven M.,Criscione, Kevin R.,McLeish, Michael J.,Grunewald, Gary L.. "Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: Design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the α2-adrenoceptor". . p. 4483 - 4493. Retrieved 2007/10/03.