Acetic acid, [2-(phenylmethoxy)ethoxy]-, methyl ester

Base Information

• Chemical Name: Acetic acid, [2-(phenylmethoxy)ethoxy]-, methyl ester
• CAS No.: 93206-15-6
• Molecular Formula: C12H16O4
• Molecular Weight: 224.257
• Mol file: 93206-15-6.mol

Synonyms:(2-Benzyloxy-ethoxy)-acetic acid methyl ester;methyl 2-(2-(benzyloxy)ethoxy)acetate;methyl 2-benzyloxyethoxyacetate;methyl [2-(benzyloxy)ethoxy]acetate;

Chemical Property of Acetic acid, [2-(phenylmethoxy)ethoxy]-, methyl ester

Chemical Property:

• Boiling Point: 319.4±22.0 °C(Predicted)
• PSA: 44.76000
• Density: 1.096±0.06 g/cm3(Predicted)
• LogP: 1.39280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid, [2-(phenylmethoxy)ethoxy]-, methyl ester

There total 2 articles about Acetic acid, [2-(phenylmethoxy)ethoxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-Benzyloxyethanol (622-08-2,1201808-31-2) + bromoacetic acid methyl ester (96-32-2) → <2-(benzyloxy)ethoxy>acetic acid methylester (93206-15-6)

Guidance literature:

2-Benzyloxyethanol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

bromoacetic acid methyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/bc100202y

Reference yield: 63.3%

3-benzyloxypropan-1-ol (4799-68-2) + bromoacetic acid methyl ester (96-32-2) → <2-(benzyloxy)ethoxy>acetic acid methylester (93206-15-6)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; sodium hydroxide; In dichloromethane; at 30 ℃; for 72h;

Reference yield: 95.0%

<2-(benzyloxy)ethoxy>acetic acid methylester (93206-15-6) → <2-(benzyloxy)ethoxy>acetic acid (93206-09-8)

Guidance literature:

With methanol; potassium hydroxide; at 35 ℃; for 1h;

DOI:10.1021/bc100202y

upstream raw materials:

2-Benzyloxyethanol

bromoacetic acid methyl ester

3-benzyloxypropan-1-ol

Downstream raw materials:

2-benzyloxyethoxyacetamide

2-benzyloxyethoxythioacetamide

2-(2-benzyloxyethoxymethyl)thiazole-4-carboxamide

ethyl 2-(2-benzyloxyethoxymethyl)thiazole-4-carboxylate