4-(Carboxymethyl)-2-(2-methylphenoxy)benzoic acid

Base Information

Chemical Name:4-(Carboxymethyl)-2-(2-methylphenoxy)benzoic acid
CAS No.:93273-61-1
Molecular Formula:C16H14O5
Molecular Weight:286.284
Hs Code.:
DSSTox Substance ID:DTXSID10537751
Wikidata:Q82412849

Synonyms:93273-61-1;4-(Carboxymethyl)-2-(2-methylphenoxy)benzoic acid;DTXSID10537751

Suppliers and Price of 4-(Carboxymethyl)-2-(2-methylphenoxy)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(Carboxymethyl)-2-(2-methylphenoxy)benzoic acid

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:286.08412354
Heavy Atom Count:21
Complexity:381

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=CC=C1OC2=C(C=CC(=C2)CC(=O)O)C(=O)O

Technology Process of 4-(Carboxymethyl)-2-(2-methylphenoxy)benzoic acid

There total 6 articles about 4-(Carboxymethyl)-2-(2-methylphenoxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.2%

: 55689-65-1
oxepinac

: 23560-72-7
3-Methyl-6,11-dihydrodibenzoxepin-11-one

: 84-54-8
2-methylanthracene-9,10-dione

: 93273-62-2
4-(2-carboxybenzyl)-3-hydroxyphenylacetic acid

: 93273-61-1
4-carboxy-3-(2-methylphenoxy)phenylacetic acid

Guidance literature:: With sodium hydroxide; In water; for 336h; Irradiation;
DOI:10.1248/cpb.32.3047

Reference yield:

: 56759-32-1
1-(4-amino-3-bromophenyl)-ethanone

: 93273-61-1
4-carboxy-3-(2-methylphenoxy)phenylacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaNO₂, conc. HCl / 1.) H₂O, 5 deg C; 2.) 0.5 h

2: 93.4 percent / conc. H₂SO₄ / H₂O; acetic acid / 5 h / Heating

3: 65.5 percent / K₂CO₃, Cu / 2 h / 157 - 170 °C

4: 95.1 percent / conc. H₂SO₄ / 4.5 h / Heating

5: 1.) sulfur, morpholine; 2.) KOH / 1.) reflux, 17 h; 2:) H₂O, 95percent EtOH, reflux, 16 h

With morpholine; hydrogenchloride; potassium hydroxide; sulfuric acid; copper; potassium carbonate; sulfur; sodium nitrite; In water; acetic acid;
DOI:10.1248/cpb.32.3047

Reference yield:

: 93273-63-3
4-acetyl-2-bromobenzonitrile

: 93273-61-1
4-carboxy-3-(2-methylphenoxy)phenylacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 93.4 percent / conc. H₂SO₄ / H₂O; acetic acid / 5 h / Heating

2: 65.5 percent / K₂CO₃, Cu / 2 h / 157 - 170 °C

3: 95.1 percent / conc. H₂SO₄ / 4.5 h / Heating

4: 1.) sulfur, morpholine; 2.) KOH / 1.) reflux, 17 h; 2:) H₂O, 95percent EtOH, reflux, 16 h

With morpholine; potassium hydroxide; sulfuric acid; copper; potassium carbonate; sulfur; In water; acetic acid;
DOI:10.1248/cpb.32.3047