1-Methyl-4-[2-amino]benzoyl piperazine

Base Information

• Chemical Name: 1-Methyl-4-[2-amino]benzoyl piperazine
• CAS No.: 93288-86-9
• Molecular Formula: C12H17N3O
• Molecular Weight: 219.28300
• Hs Code.: 2933599090
• Mol file: 93288-86-9.mol

Synonyms:2-aminophenyl 4-methylpiperazinyl ketone;

Chemical Property of 1-Methyl-4-[2-amino]benzoyl piperazine

Chemical Property:

• PSA: 49.57000
• LogP: 1.11340
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(2-aminophenyl)(4-methylpiperazin-1-yl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-4-[2-amino]benzoyl piperazine

There total 7 articles about 1-Methyl-4-[2-amino]benzoyl piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-methyl-1-<2-<(2-methyl-1-phenylpropen-1-yl)amino>benzoyl>piperazine (137434-55-0) → 1-(2-aminobenzoyl)-4-methylpiperazine (93288-86-9)

Guidance literature:

With hydrogenchloride; In ethanol; at 50 ℃; for 1h;

DOI:10.1021/jo00027a037

Reference yield:

lithium 4-methylpiperazin-1-ide (105563-31-3) → 1-(2-aminobenzoyl)-4-methylpiperazine (93288-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / diethyl ether

2: 70 percent / 1N HCl / ethanol / 1 h / 50 °C

With hydrogenchloride; In diethyl ether; ethanol;

DOI:10.1021/jo00027a037

Reference yield:

(E)-N-(2-methyl-1-phenylpropylidene)-2-(trifluoromethyl)aniline (137434-54-9) → 1-(2-aminobenzoyl)-4-methylpiperazine (93288-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / diethyl ether

2: 70 percent / 1N HCl / ethanol / 1 h / 50 °C

With hydrogenchloride; In diethyl ether; ethanol;

DOI:10.1021/jo00027a037

upstream raw materials:

1-methyl-4-(2-nitrobenzoyl)piperazine

4-methyl-1-<2-<(2-methyl-1-phenylpropen-1-yl)amino>benzoyl>piperazine

lithium 4-methylpiperazin-1-ide

(E)-N-(2-methyl-1-phenylpropylidene)-2-(trifluoromethyl)aniline

Refernces

• 1、 Cervena, Irena,Protiva, Miroslav. "1--4-METHYLPIPERAZINE AND RELATED COMPOUNDS AS POTENTIAL ANTIDEPRESSANTS: SYNTHESIS AND PHARMACOLOGICAL SCREENING". . p. 1009 - 1020. Retrieved 2007/10/02.