2-(2,4,6-Trimethylphenyl)isoindole-1,3-dione

Base Information

• Chemical Name: 2-(2,4,6-Trimethylphenyl)isoindole-1,3-dione
• CAS No.: 93315-97-0
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.312
• UNII: G6P5ZXZ8L4
• Nikkaji Number: J2.873.611H
• Mol file: 93315-97-0.mol

Synonyms:2-(2,4,6-trimethylphenyl)isoindole-1,3-dione;2-mesityl-1H-isoindole-1,3(2H)-dione;2-(2,4,6-trimethylphenyl)-1H-isoindole-1,3(2H)-dione;N-Mesitylphthalimide;CBMicro_016951;G6P5ZXZ8L4;Oprea1_399866;Oprea1_513401;93315-97-0;SCHEMBL19838232;CCG-5868;STK035868;AKOS000488084;N-(2,4,6-Trimethylphenyl)phthalimide;BIM-0016856.P001;AN-329/10730049;SR-01000204131;SR-01000204131-1;2-(2,4,6-Trimethylphenyl)-2H-isoindole-1,3-dione

Chemical Property of 2-(2,4,6-Trimethylphenyl)isoindole-1,3-dione

Chemical Property:

• Melting Point: 154 - 156 °C
• PSA: 37.38000
• LogP: 3.47740
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 265.110278721
• Heavy Atom Count: 20
• Complexity: 383

Purity/Quality:

2-mesityl-1H-isoindole-1,3(2H)-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)C)N2C(=O)C3=CC=CC=C3C2=O)C

Technology Process of 2-(2,4,6-Trimethylphenyl)isoindole-1,3-dione

There total 15 articles about 2-(2,4,6-Trimethylphenyl)isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phthalic anhydride (85-44-9) + 2,4,6-trimethylaniline (88-05-1) → 1-(N-phthalimido)-2,4,6-trimethylbenzene (93315-97-0)

Guidance literature:

With acetic acid; at 150 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c9cc05280a

Reference yield: 89.0%

N-(trifluoromethyl)acyloxyphthalimide (5672-90-2) + 1,3,5-trimethyl-benzene (108-67-8) → 1-(N-phthalimido)-2,4,6-trimethylbenzene (93315-97-0)

Guidance literature:

With tris[2-phenylpyridinato-C₂,N]iridium(III); In acetonitrile; at 20 ℃; for 24h; Sealed tube; Irradiation;

DOI:10.1021/ja501906x

Reference yield: 83.0%

phthalimide (136918-14-4,85-41-6) + 1,3,5-trimethyl-benzene (108-67-8) → 1-(N-phthalimido)-2,4,6-trimethylbenzene (93315-97-0)

Guidance literature:

With [bis(acetoxy)iodo]benzene; iodine; In dichloromethane; at 20 ℃; for 12h; Irradiation;

DOI:10.1021/acs.orglett.0c00433

upstream raw materials:

phthalic anhydride

2,4,6-trimethylaniline

1,3,5-trimethyl-benzene

phthalimide

Downstream raw materials:

phthalic anhydride

2,4,6-trimethylaniline