3-bromo-4-phenylthiophene

Base Information

• Chemical Name: 3-bromo-4-phenylthiophene
• CAS No.: 23062-41-1
• Molecular Formula: C10H7 Br S
• Molecular Weight: 239.136
• Mol file: 23062-41-1.mol

Synonyms:3-Bromo-4-phenylthiophene;NSC 149723

Chemical Property of 3-bromo-4-phenylthiophene

Chemical Property:

• Vapor Pressure: 0.0156mmHg at 25°C
• Boiling Point: 264.8°Cat760mmHg
• Flash Point: 113.9°C
• Density: 1.49g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-bromo-4-phenylthiophene

There total 10 articles about 3-bromo-4-phenylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,4-dibromothiophene (3141-26-2) + phenylboronic acid (98-80-6) → 3-bromo-4-phenylthiophene (23062-41-1)

Guidance literature:

phenylboronic acid; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium carbonate; triphenylphosphine; In toluene; at 20 ℃; Inert atmosphere;

3,4-dibromothiophene; In toluene; Inert atmosphere;

With sodium carbonate; In toluene; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.1021/jm201556r

Reference yield: 92.0%

2,4,5-tribromo-3-phenylthiophene (500772-23-6) → 3-bromo-4-phenylthiophene (23062-41-1)

Guidance literature:

With n-butyllithium; In diethyl ether; at -70 ℃; for 2h;

DOI:10.1021/jo026298o

Reference yield: 70.0%

3-Bromothiophene (872-31-1) + phenylboronic acid (98-80-6) → 3-bromo-4-phenylthiophene (23062-41-1)

Guidance literature:

With palladium(II) trifluoroacetate; cesium trifluoroacetate; trifluoroacetic acid; p-benzoquinone; silver(l) oxide; In acetic acid; at 20 ℃; for 4h;

DOI:10.1002/chem.201402765

upstream raw materials:

3,4-dibromothiophene

iodobenzene

2,4,5-tribromo-3-phenylthiophene

3-phenylthiophene

Downstream raw materials:

3-phenyl-4-[(4-phenylthien-3-yl)thio]thiophene

8H-Indeno<1,2-c>thiophen-8-on

4-phenylthiophene-3-carboxylic acid

1,1'-bis-(toluene-4-sulfonyl)-1H,1'H-[3,3']biindolyl

Refernces

• 1、 -. "METHOD OF PRODUCING HALOGEN COMPOUND". Paragraph 0052-0060; 0088-0090. . Retrieved 2021/05/07.
• 2、 Tang, Dan-Tam D.,Collins, Karl D.,Ernst, Johannes B.,Glorius, Frank. "Pd/C as a catalyst for completely regioselective c=h functionalization of thiophenes under mild conditions". supporting information. p. 1809 - 1813. Retrieved 2014/03/21.