1-(Morpholin-4-yl)-2,3-diphenylpropan-1-one

Base Information

• Chemical Name: 1-(Morpholin-4-yl)-2,3-diphenylpropan-1-one
• CAS No.: 93378-48-4
• Molecular Formula: C19H21NO2
• Molecular Weight: 295.381
• DSSTox Substance ID: DTXSID20539665
• Mol file: 93378-48-4.mol

Synonyms:93378-48-4;1-(Morpholin-4-yl)-2,3-diphenylpropan-1-one;DTXSID20539665

Chemical Property of 1-(Morpholin-4-yl)-2,3-diphenylpropan-1-one

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 295.157228913
• Heavy Atom Count: 22
• Complexity: 339

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1COCCN1C(=O)C(CC2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-(Morpholin-4-yl)-2,3-diphenylpropan-1-one

There total 3 articles about 1-(Morpholin-4-yl)-2,3-diphenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

phenylboronic acid (98-80-6) + 1-morpholino-2-phenylprop-2-en-1-one (19199-46-3) → 1-morpholino-2,3-diphenylpropan-1-one (93378-48-4)

Guidance literature:

With (μ2-Br)2Mn2(CO)8; ethanol; cesium fluoride; In diethyl ether; at 120 ℃; for 20h; chemoselective reaction; Schlenk technique;

DOI:10.1002/anie.201916305

Reference yield: 24.0%

N-morpholinocinnamide (16619-19-5,21497-11-0) + iodobenzene (591-50-4) → 1-morpholino-2,3-diphenylpropan-1-one (93378-48-4) + 1-(morpholin-4-yl)-3,3-diphenylpropan-1-one

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetramethylammonium formiate; P(p-C₆H₄F)3; In 1,4-dioxane; water; at 100 ℃; Sealed tube;

DOI:10.1021/jacs.0c03040

Reference yield:

N-(phenylacetyl)morpholine (17123-83-0) + benzyl chloride (100-44-7) → 1-morpholino-2,3-diphenylpropan-1-one (93378-48-4)

Guidance literature:

Multistep reaction; (i) NaNH₂, (ii) /BRN= 471308/;

upstream raw materials:

N-(phenylacetyl)morpholine

benzyl chloride

phenylboronic acid

1-morpholino-2-phenylprop-2-en-1-one

Downstream raw materials:

4-(2-benzyl-4-morpholin-4-yl-2-phenyl-butyryl)-morpholine