Technology Process of (4R)-5-(Phenylmethoxy)-1,4-pentanediol
There total 5 articles about (4R)-5-(Phenylmethoxy)-1,4-pentanediol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-1-benzyloxypent-4-en-2-ol;
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
at 0 - 20 ℃;
Inert atmosphere;
With
sodium hydroxide; dihydrogen peroxide;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1002/chem.200801024
- Guidance literature:
-
With
methanol; lithium borohydride;
In
tetrahydrofuran;
at 0 - 5 ℃;
for 16h;
Inert atmosphere;
DOI:10.1002/anie.200805241
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 74 percent / trifluoromethanesulfonic acid / CH2Cl2; pentane / 0.5 h / 0 °C
2: DIBAL / toluene / 1 h / -78 °C
With
trifluorormethanesulfonic acid; diisobutylaluminium hydride;
In
dichloromethane; toluene; pentane;
DOI:10.1021/ja000001r
