1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol

Base Information

• Chemical Name: 1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol
• CAS No.: 93413-86-6
• Molecular Formula: C16H25NO
• Molecular Weight: 247.37600
• Mol file: 93413-86-6.mol

Synonyms:1-[2-(Dimethylamino)-1-phenylethyl]cyclohexanol;

Chemical Property of 1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol

Chemical Property:

• Boiling Point: 356.4±25.0 °C (760 mmHg)
• PSA: 23.47000
• Density: 1.040±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 3.02700

Purity/Quality:

>95% ^*data from raw suppliers

1-[2-(Dimethylamino)-1-phenylethyl]cyclohexanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-[2-(Dimethylamino)-1-phenylethyl]cyclohexanol is used in the synthesis of ethylamine derivatives displaying antidepressant activity.

Technology Process of 1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol

There total 8 articles about 1-[2-(DiMethylaMino)-1-phenylethyl]cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + N,N-dimethylphenethylamine (1126-71-2) → 1-[2-(dimethylamino)-1-phenylethyl]cyclohexanol (93413-86-6)

Guidance literature:

With potassium tert-butylate; tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 - -60 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c2cc35888c

Reference yield:

3N-isopropanolic HCl + 1-[α-(aminomethyl)benzyl]cyclohexanol → 1-[2-(dimethylamino)-1-phenylethyl]cyclohexanol (93413-86-6)

Guidance literature:

With formaldehyd; formic acid; In water;

Reference yield:

4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenyl diethyl phosphate → 1-[2-(dimethylamino)-1-phenylethyl]cyclohexanol (93413-86-6)

Guidance literature:

With 1,3-dicyano-2,4,5,6-tetrakis(N,N-diphenylamino)-benzene; tert-butylammonium hexafluorophosphate(V); triethylamine; In N,N-dimethyl-formamide; for 12h; Inert atmosphere; Sealed tube; Irradiation; Electrolysis;

DOI:10.1002/anie.202107169

upstream raw materials:

phenylacetic acid

N,N-dimethyl-2-phenylacetamide

cyclohexanone

N,N-dimethylphenethylamine