Technology Process of 1H-Pyrrolo[1,2-a]indole-9-carboxylic acid,
2-(acetylamino)-2,3,5,6,7,8-hexahydro-6-methyl-8-oxo-, phenylmethyl
ester
There total 11 articles about 1H-Pyrrolo[1,2-a]indole-9-carboxylic acid,
2-(acetylamino)-2,3,5,6,7,8-hexahydro-6-methyl-8-oxo-, phenylmethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic anhydride;
In
tetrahydrofuran;
at 60 ℃;
for 1h;
DOI:10.1021/jo00200a031
- Guidance literature:
-
Multi-step reaction with 11 steps
2: 1)a) Ac2O, 60 deg C, 15 min b) 80 deg C, 30 min 2) 135 deg C, 3 h
3: 94 percent / 2percent sodium methoxide / methanol / 1 h / Ambient temperature
4: 95 percent / Et3N / tetrahydrofuran / 1) 0 deg C, 30 min 2) room temperature, 40 min
5: 93 percent / NaN3 / dimethylformamide; H2O / 90 - 100 °C
6: 85 percent / Hydrogen / 10percent Pd/C / ethanol / 24 h / 760 Torr
7: 98 percent / 2 h / Ambient temperature
8: 1) potassium tert-butoxide 2) 3percent HCl / 1) THF, room temperature, 30 min 2) water
9: 2percent NaOH / methanol; H2O / 1) cooling 2) room temperature
10: concentrated HCl / methanol; H2O / 0 °C
11: 79 percent / Trifluoroacetic anhydride / tetrahydrofuran / 1 h / 60 °C
With
hydrogenchloride; sodium hydroxide; sodium azide; potassium tert-butylate; hydrogen; sodium methylate; triethylamine; trifluoroacetic anhydride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00200a031
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 95 percent / Et3N / tetrahydrofuran / 1) 0 deg C, 30 min 2) room temperature, 40 min
2: 93 percent / NaN3 / dimethylformamide; H2O / 90 - 100 °C
3: 85 percent / Hydrogen / 10percent Pd/C / ethanol / 24 h / 760 Torr
4: 98 percent / 2 h / Ambient temperature
5: 1) potassium tert-butoxide 2) 3percent HCl / 1) THF, room temperature, 30 min 2) water
6: 2percent NaOH / methanol; H2O / 1) cooling 2) room temperature
7: concentrated HCl / methanol; H2O / 0 °C
8: 79 percent / Trifluoroacetic anhydride / tetrahydrofuran / 1 h / 60 °C
With
hydrogenchloride; sodium hydroxide; sodium azide; potassium tert-butylate; hydrogen; triethylamine; trifluoroacetic anhydride;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00200a031
