Technology Process of 1,1-Cyclohexanedicarboxylic acid, 4-(1-methyl-2-phenyl-1H-indol-3-yl)-,
monomethyl ester, cis-
There total 7 articles about 1,1-Cyclohexanedicarboxylic acid, 4-(1-methyl-2-phenyl-1H-indol-3-yl)-,
monomethyl ester, cis- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide; water;
In
methanol;
for 1h;
Heating;
DOI:10.1021/jm00380a002
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 42 percent / 85 percent H3PO4, AcOH, Ac2O / 72 h / Ambient temperature
2: 1.) K2CO3 / 1.) DMF, RT, 2 h, 2.) DMF, reflux, 4 h
3: 1.) NaH (50 percent in oil) / 1.) DMF, 50 deg C, 2 h, 2.) DMF, a) RT, overnight, b) 50 deg C, 3 h
4: H2 / 10 percent Pd/C / dioxane / 3 h / Ambient temperature
5: 42 percent / KOH, H2O / methanol / 1 h / Heating
With
potassium hydroxide; phosphoric acid; water; hydrogen; acetic anhydride; sodium hydride; potassium carbonate; acetic acid;
palladium on activated charcoal;
In
1,4-dioxane; methanol;
DOI:10.1021/jm00380a002
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 42 percent / 85 percent H3PO4, AcOH, Ac2O / 72 h / Ambient temperature
2: 1.) K2CO3 / 1.) DMF, RT, 2 h, 2.) DMF, reflux, 4 h
3: 1.) NaH (50 percent in oil) / 1.) DMF, 50 deg C, 2 h, 2.) DMF, a) RT, overnight, b) 50 deg C, 3 h
4: H2 / 10 percent Pd/C / dioxane / 3 h / Ambient temperature
5: 42 percent / KOH, H2O / methanol / 1 h / Heating
With
potassium hydroxide; phosphoric acid; water; hydrogen; acetic anhydride; sodium hydride; potassium carbonate; acetic acid;
palladium on activated charcoal;
In
1,4-dioxane; methanol;
DOI:10.1021/jm00380a002
