2-Chloro-1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxylic acid

Base Information

Chemical Name:2-Chloro-1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxylic acid
CAS No.:93548-90-4
Molecular Formula:C16H11Cl2NO2
Molecular Weight:320.175
Hs Code.:
DSSTox Substance ID:DTXSID001175260

Synonyms:SCHEMBL12749049;DTXSID001175260;2-Chloro-1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxylic acid;93548-90-4

Suppliers and Price of 2-Chloro-1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Chloro-1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxylic acid

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:319.0166840
Heavy Atom Count:21
Complexity:385

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(=C(N2CC3=CC=C(C=C3)Cl)Cl)C(=O)O

Technology Process of 2-Chloro-1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxylic acid

There total 3 articles about 2-Chloro-1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5059-30-3
2-chloroindole-3-carboxaldehyde

: 93548-90-4
2-Chloro-1-(4-chloro-benzyl)-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.17 h / 20 °C

1.2: dimethylformamide / 90 °C

2.1: KMnO₄ / acetone; H₂O / 20 °C

With potassium permanganate; sodium hydride; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2004.06.008

Reference yield:

: 75621-51-1
1-(4-Chlorobenzyl)-2-chloroindole-3-carboxaldehyde

: 93548-90-4
2-Chloro-1-(4-chloro-benzyl)-1H-indole-3-carboxylic acid

Guidance literature:: With potassium permanganate; In water; acetone; for 16h; Yield given; Ambient temperature;
DOI:10.1002/ardp.19843171007

Reference yield:

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 93548-90-4
2-Chloro-1-(4-chloro-benzyl)-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.17 h / 20 °C

1.2: dimethylformamide / 90 °C

2.1: KMnO₄ / acetone; H₂O / 20 °C

With potassium permanganate; sodium hydride; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2004.06.008