4-amino-1-[(2R,5S)-5-(aminomethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2(1H)-one

Base Information

• Chemical Name: 4-amino-1-[(2R,5S)-5-(aminomethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2(1H)-one
• CAS No.: 62748-91-8
• Molecular Formula: C₉H₁₂N₄O₂
• Molecular Weight: 208.22

Synonyms:5'-AMINO-2',3'-DIDEHYDRO-2',3',5'-TRIDEOXYCYTIDINE;Cytidine,5'-amino-2',3'-didehydro-2',3',5'-trideoxy;5'-NH2-D4C;5'-Amino-2',3'-dideoxdidehydroycytidine;

Chemical Property of 4-amino-1-[(2R,5S)-5-(aminomethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2(1H)-one

Chemical Property:

• Vapor Pressure: 1.23E-06mmHg at 25°C
• Boiling Point: 400.9°C at 760 mmHg
• PKA: 9.26±0.29(Predicted)
• Flash Point: 196.2°C
• PSA: 97.15000
• Density: 1.56g/cm³
• LogP: 0.28050

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-amino-1-[(2R,5S)-5-(aminomethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2(1H)-one

There total 1 articles about 4-amino-1-[(2R,5S)-5-(aminomethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-(5-amino-2,3,5-trideoxy-β-D-glycero-pent-2-enofuranosyl)cytosine (62748-91-8)

Guidance literature:

/BRN= 679448/, H2S/Pyridin;

Reference yield: 84.0%

NPS-L-Phe-OSu (20727-56-4) + 1-(5-amino-2,3,5-trideoxy-β-D-glycero-pent-2-enofuranosyl)cytosine (62748-91-8) → (S)-N-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl]-2-(2-nitro-phenylsulfanylamino)-3-phenyl-propionamide (70545-41-4)

Guidance literature:

In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0008-6215(00)83661-7

Reference yield: 76.0%

(S)-4-Methylsulfanyl-2-(2-nitro-phenylsulfanylamino)-butyric acid 4-nitro-phenyl ester (41960-99-0) + 1-(5-amino-2,3,5-trideoxy-β-D-glycero-pent-2-enofuranosyl)cytosine (62748-91-8) → (S)-N-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl]-4-methylsulfanyl-2-(2-nitro-phenylsulfanylamino)-butyramide (73074-26-7)

Guidance literature:

In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0008-6215(00)83661-7

Downstream raw materials:

(R)-N-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl]-2-(2-nitro-phenylsulfanylamino)-2-phenyl-acetamide

(S)-N-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl]-2-(2-nitro-phenylsulfanylamino)-3-phenyl-propionamide

(S)-N-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl]-4-methylsulfanyl-2-(2-nitro-phenylsulfanylamino)-butyramide

(S)-N-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-2,5-dihydro-furan-2-ylmethyl]-3-(4-methoxy-phenyl)-2-(2-nitro-phenylsulfanylamino)-propionamide

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