Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-phenyl-, hydrochloride, cis-(-)-

Base Information

Chemical Name:Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-phenyl-, hydrochloride, cis-(-)-
CAS No.:54088-36-7
Molecular Formula:C₁₉H₂₁NO₃*ClH
Molecular Weight:347.842
Hs Code.:
DSSTox Substance ID:DTXSID50202416

Synonyms:cis-(-)-3-((1,3-Benzodioxol-5-yloxy)methyl)-4-phenylpiperidine hydrochloride;Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-phenyl-, hydrochloride, cis-(-)-;54088-36-7;DTXSID50202416;LS-114254

Suppliers and Price of Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-phenyl-, hydrochloride, cis-(-)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-phenyl-, hydrochloride, cis-(-)-

Chemical Property:

Vapor Pressure:2.03E-08mmHg at 25°C
Boiling Point:453.6°Cat760mmHg
Flash Point:189.2°C
Density:g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:347.1288213
Heavy Atom Count:24
Complexity:372

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCC(C1C2=CC=CC=C2)COC3=CC4=C(C=C3)OCO4.Cl
Isomeric SMILES:C1CNC[C@@H]([C@@H]1C2=CC=CC=C2)COC3=CC4=C(C=C3)OCO4.Cl

Technology Process of Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-phenyl-, hydrochloride, cis-(-)-

There total 8 articles about Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-phenyl-, hydrochloride, cis-(-)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 176022-03-0
(-)-trans-3-hydroxymethyl-1-methyl-4-phenylpiperidine

: 54088-36-7
(-)-trans-3-(3,4-methylenedioxyphenoxymethyl)-4-phenylpiperidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / thionyl chloride / CHCl₃ / 6 h / Heating

2: 61 percent / sodium hydride / dimethylformamide / 3 h / 120 °C / then room temperature 60 h

3: 1.) BrCN, 2.) LiAlH₄

With lithium aluminium tetrahydride; thionyl chloride; bromocyane; sodium hydride; In chloroform; N,N-dimethyl-formamide;
DOI:10.3891/acta.chem.scand.50-0164

Reference yield:

: 176022-01-8
(-)-trans-3-chloromethyl-1-methyl-4-phenylpiperidine

: 54088-36-7
(-)-trans-3-(3,4-methylenedioxyphenoxymethyl)-4-phenylpiperidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / sodium hydride / dimethylformamide / 3 h / 120 °C / then room temperature 60 h

2: 1.) BrCN, 2.) LiAlH₄

With lithium aluminium tetrahydride; bromocyane; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.3891/acta.chem.scand.50-0164

Reference yield:

: Femoxetine hydrochloride

: 54088-36-7
(+)-trans-3-(3,4-methylenedioxyphenoxymethyl)-4-phenylpiperidine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 65 g / pyridine, hydrochloric acid / 16 h / 160 °C

2: 4.6 g / hydrochloric acid, K₂Cr₂O₇ / H₂O / 0.5 h / 80 °C

3: thionyl chloride / CHCl₃ / 6 h / Heating

4: sodium hydride / dimethylformamide / 3 h / 120 °C / then room temperature 60 h

5: 1.) BrCN, 2.) LiAlH₄

With pyridine; hydrogenchloride; potassium dichromate; lithium aluminium tetrahydride; thionyl chloride; bromocyane; sodium hydride; In chloroform; water; N,N-dimethyl-formamide;
DOI:10.3891/acta.chem.scand.50-0164